玻璃体腔注射雷珠单抗的针对性护理对湿性黄斑变性及玻璃体出血情况的影响  

Effect of Targeted Nursing with Intravitreal Injection of Ranibizumab on Wet Macular Degeneration and Vitreous Hemorrhage

作　　者：周同英 ZHOU Tongying(Ophthalmology Department,Huai'an City the First People's Hospital,Huai'an,Jiangsu 223001)

机构地区：[1]淮安市第一人民医院眼科,江苏淮安223001

出　　处：《智慧健康》2024年第7期215-218,共4页Smart Healthcare

摘　　要：目的 探讨玻璃体腔注射雷珠单抗的针对性护理对湿性黄斑变性及玻璃体出血情况的影响。方法 选取2019年3月—2022年3月淮安第一人民医院眼科收治的68例湿性黄斑变性患者作为研究样本,按随机数字表法分观察组(34例)和对照组(34例)。对照组患者实施常规护理干预,观察组患者开展玻璃体腔注射雷珠单抗的针对性护理。比较两组患者护理前后的炎症因子(SDFl-ɑ、LIF)、最佳矫正视力(BCVA),及黄斑中心凹厚度(CMT)、血清血管生成调节因子[VEGF、基质金属蛋白酶抑制剂-1(TIMP-1)、内皮抑素(ES)、血小板衍生生长因子(PDGF)]水平及玻璃体出血情况。结果 护理后,两组SDFl-ɑ和LIF水平均有所下降,且观察组治疗后SDFl-ɑ和LIF水平均明显低于对照组(P<0.05)。护理前,两组BCVA、CMT比较无统计学差异(P>0.05);护理1个月、2个月、3个月,观察组患者的BCVA高于对照组,CMT低于对照组(P<0.05)。护理后观察组患者血清VEGF、PDGF水平明显高于对照组,血清TIMP-1、ES水平明显低于对照组(P<0.05)。两组患者均无玻璃体出血情况。结论 对于湿性黄斑变性患者玻璃体腔注射雷珠单抗的针对性护理效果显著,具备一定的安全性,值得临床广泛推广。Objective To explore effect of targeted nursing with intravitreal injection of ranibizumab on wet macular degeneration and vitreous hemorrhage.Methods The paper chose 68patients with wet macular degeneration admitted to ophthalmology department of Huai'an City the First People's Hospital from March 2019 to March 2022 as study samples,and divided them into observation group of 34 cases and control group of 34 cases with random number table method.Control group was treated with routine nursing intervention,while observation group with targeted nursing for intravitreal injection of ranibizumab.Inflammatory factors(SDFl-ɑ),LIF levels,best corrected visual acuity(BCVA),macular fovea thickness(CMT),serum levels of angiogenic regulatory factors VEGF,matrix metalloproteinase inhibitor-1(TIMP-1),endostatin(ES),platelet derived growth factor(PDGF),and vitreous hemorrhage status were compared before and after nursing between two groups.Results After nursing,SDFl-ɑ and LIF levels decreased,SDFl-ɑ and LIF levels in observation group after treatment were significantly lower than control group(P<0.05).Before nursing,there was no statistically significant difference in BCVA and CMT between two groups(P>0.05).After nursing for 1 month,2 months,and 3 months,BCVA of observation group was higher than control group,while CMT was lower than control group(P<0.05).After nursing,serum levels of VEGF and PDGF in observation group were significantly higher than control group,while serum levels of TIMP-1 and ES were significantly lower than control group(P<0.05).There was no vitreous hemorrhage in two groups.Conclusion Targeted nursing can achieve significant effect for patients with wet macular degeneration treated with intravitreal injection of ranibizumab,with some certain degree of safety,which is worthy of widely clinical promotion.

关 键 词：玻璃体腔注射 雷珠单抗 针对性护理 湿性黄斑变性 玻璃体出血 

分 类 号：R473.77[医药卫生—护理学]