复方桐叶烧伤油联合重组人碱性成纤维细胞生长因子凝胶治疗喉癌术后咽漏的疗效研究  

Effect of compound TongYe burn oil combined with recombinant human basic fibroblast growth factor gel in the treatment of pharyngeal leakage after laryngeal cancer operation

作　　者：陈薇[1] 杨勇[1] 张梦颖 CHEN Wei;YANG Yong;ZHANG Mengying(Jiangxi Provincial People′s Hospital/The First Affiliated Hospital of Nanchang Medical College,Nanchang,Jiangxi 330000,China)

机构地区：[1]江西省人民医院/南昌医学院第一附属医院,江西南昌330000

出　　处：《现代医药卫生》2024年第9期1473-1475,1479,共4页Journal of Modern Medicine & Health

基　　金：江西省中医药管理局资助项目(2022B479)。

摘　　要：目的研究喉癌术后咽漏患者应用复方桐叶烧伤油联合重组人碱性成纤维细胞生长因子凝胶(rh-bFGF)治疗的疗效。方法选取2018年1月至2022年12月本院收治的行喉癌切除术后咽漏患者60例,采用随机数字表法分为治疗组和对照组,每组30例。治疗组使用复方桐叶烧伤油联合rh-bFGF纱条进行局部换药,对照组仅使用rh-bFGF纱条进行局部换药。评估咽漏疗效、治愈时间和费用。结果治疗组患者显效率[46.67%(14/30)]、总有效率[96.67%(29/30)]与对照组[30.00%(9/30)和86.67%(26/30)]比较,差异均无统计学意义(P>0.05)。治疗组患者治疗后血清白细胞介素6水平[(16.56±4.26)pg/L]均低于治疗前[(53.96±6.28)pg/L]与对照组[(24.35±3.61)pg/L],术后住院费用[(57817.7±2203.7)元]明显少于对照组[(61915.5±1972.9)元],住院时间[(19.27±2.35)d]明显短于对照组[(24.77±2.16)d],差异均有统计学意义(P<0.05)。结论复方桐叶烧伤油联合rh-bFGF治疗喉癌术后咽漏效果与常规使用rh-bFGF相当,可促进愈合,减轻炎症反应,且与常规使用rh-bFGF比较,可缩短住院时间和费用,具有较好的临床获益,值得推广应用。Objective To study the efficacy of compound TongYe burn oil combined with recombinant human basic fibroblast growth factor gel(rh-bFGF)in the treatment of patients with pharyngeal leakage after laryngeal cancer surgery.Methods A total of 60 patients with pharyngeal fistula after laryngeal cancer resection admitted to our hospital from January 2018 to December 2022 were selected and divided into treatment group and control group by random number table method,with 30 cases in each group.The treatment group was treated with compound TongYe burn oil combined with rh-bFGF gauze for local dressing change,while the control group was only treated with rh-bFGF gauze for local dressing change.The efficacy,cure time and cost of pharyngeal leakage were evaluated.Results There was no significant difference in the effective rate[46.67%(14/30)]and total effective rate[96.67%(29/30)]between the treatment group and the control group[30.00%(9/30)and 86.67%(26/30)](P>0.05).After treatment,the serum interleukin-6 level[(16.56±4.26)pg/L]in the treatment group was lower than that before treatment[(53.96±6.28)pg/L]and that in the control group[(24.35±3.61)pg/L],the postoperative hospitalization cost[(57817.7±2203.7)yuan]was significantly less than that in the control group[(61915.5±1972.9)yuan],and the hospitalization time[(19.27±2.35)d]was significantly shorter than that in the control group[(24.77±2.16)d],the differences were statistically significant(P<0.05).Conclusion The effect of compound Tongye burn oil combined with rh-bFGF in the treatment of postoperative pharyngeal leakage of laryngeal cancer is equivalent to that of routine use of rh-bFGF.It can promote healing and reduce inflammatory reaction.Compared with routine use of rh-bFGF,it can shorten hospitalization time and cost,and has good clinical benefits.It is worthy of popularization and application.

关 键 词：复方桐叶烧伤油 重组人碱性成纤维细胞生长因子凝胶 喉癌术后咽漏 

分 类 号：R766[医药卫生—耳鼻咽喉科] R739.65[医药卫生—临床医学]