TAO联合rh-bFGF凝胶对深Ⅱ度烧伤患者症状消失时间及炎症因子的影响  

Effect of TAO combined with rh-bFGF gel on symptom disappearance time and inflammatory factors in patients with deep second degree burn

作　　者：胡东升[1] HU Dongsheng(Department of Burn Surgery,The 990th Hospital of PLA Joint Logistics Support Force,Zhumadian,Henan 463000,China)

机构地区：[1]中国人民解放军联勤保障部队第九九〇医院烧伤科,河南驻马店463000

出　　处：《现代医药卫生》2024年第9期1502-1505,1510,共5页Journal of Modern Medicine & Health

摘　　要：目的探讨复方多粘菌素B软膏(TAO)联合重组牛碱性成纤维细胞生长因子(rh-bFGF)凝胶治疗深Ⅱ度烧伤患者的疗效。方法选取2022年1-11月该院收治的深Ⅱ度烧伤患者60例,采用随机数字表法分观察组和对照组,每组30例。对照组给予TAO治疗,观察组加用rh-bFGF凝胶治疗。对比2组患者临床疗效、症状消失时间、创面愈合时间、换药疼痛、炎症因子、并发症发生率及生活质量。结果观察组患者总有效率明显高于对照组的,并发症发生率明显低于对照组,中、重度疼痛程度明显低于对照组,肿胀消失时间、红斑消失时间、渗液消失时间、水疱消失时间、疼痛消失时间、创面愈合时间均明显短于对照组,差异均有统计学意义(P<0.05)。2组治疗前炎症因子、生活质量比较,差异均无统计学意义(P>0.05);观察组患者治疗后降钙素原、C反应蛋白水平均明显低于对照组,精简烧伤健康量表中的基本生活能力维度、手功能维度、情感维度、人际关系维度、性生活维度、体热维度、热敏感维度、配合治疗维度、工作维度评分均明显高于对照组,差异均有统计学意义(P<0.05)。结论TAO联合rh-bFGF凝胶治疗深Ⅱ度烧伤患者中疗效显著,能加快症状消失及创面愈合,减轻换药疼痛与炎症反应,降低并发症发生率,提高患者生活质量。Objective To investigate the efficacy of compound polymyxin B ointment(TAO)combined with recombinant bovine basic fibroblast growth factor(rh-bFGF)gel in the treatment of patients with deep second degree burns.Methods A total of 60 patients with deep Ⅱ degree burn admitted to our hospital from January to November 2022 were selected and divided into observation group and control group by random number table method,with 30 patients in each group.The control group was treated with TAO,and the observation group was treated with rh-bFGF gel.The clinical efficacy,symptom disappearance time,wound healing time,dressing pain,inflammatory factors,incidence of complications,and quality of life were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group,the incidence of complications was significantly lower than that of the control group,the degree of pain was significantly lighter than that of the control group,the swelling disappearance time,erythema disappearance time,exudate disappearance time,blister disappearance time,pain disappearance time and wound healing time were significantly shorter than those of the control group,the differences were statistically significant(P<0.05).There was no significant difference being found in the comparison of inflammatory factors and quality of life between the two groups before treatment(P>0.05).After treatment,the levels of procalcitonin and C-reactive protein in the observation group were significantly lower than those in the control group.The scores of basic living ability dimension,hand function dimension,emotional dimension,interpersonal relationship dimension,sexual life dimension,body heat dimension,heat sensitivity dimension,cooperation treatment dimension and work dimension in the simplified burn health scale were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion TAO combined with rh-bFGF gel is effective in the

关 键 词：深Ⅱ度烧伤 复方多粘菌素B软膏 重组牛碱性成纤维细胞生长因子凝胶 炎症因子 生活质量 

分 类 号：R644[医药卫生—外科学]