2012-2022年河北口岸出入境人员新发现HIV感染者多指标检测结果分析  

Analysis of Multi-index Test Results of Newly Found HIV Infected Persons among Entry-exit Personnel at Hebei Port from 2012 to 2022

作　　者：朱君娜 闫冀焕[2] Zhu Junna;Yan Jihuan(Tianjin Second People’s Hospital,Tianjin 300100;Hebei International Travel Health Care Center Shijia-zhuang Customs Port Outpatient,Shijiazhuang Hebei 050091)

机构地区：[1]天津市第二人民医院检验科,天津300100 [2]河北国际旅行卫生保健中心石家庄海关口岸门诊部,河北石家庄050091

出　　处：《口岸卫生控制》2024年第2期20-24,共5页Port Health Control

基　　金：河北省重点研发计划项目(213777109D)。

摘　　要：目的 回顾性分析河北口岸2012-2022年新发现艾滋病病毒(HIV)感染者实验室多指标结果,为开展艾滋病防治提供依据。方法 采集新发现HIV抗体阳性感染者和健康对照静脉血,进行血常规、血清总蛋白、谷丙转氨酶、谷草转氨酶、尿素氮、肌酐、乳酸脱氢酶、钙、磷、血沉、CD4、CD8、CD4/CD8、免疫球蛋白和补体C3测定,并对检测结果进行统计分析。结果 68例HIV感染者中男性数量明显超过了女性,30~50岁年龄段人群的感染率相对较高,职业特征显示为劳务人员HIV感染率最高,性接触仍旧是出入境人员最常见的感染方式。血液细胞检测显示,血沉异常率为100%,CD4/CD8异常率高达91.18%,明显出现T细胞亚群倒置现象。生化检测显示,总蛋白(76.47%)、ALT(72.06%)、AST(77.94%)异常率均大于70%。CD4细胞绝对值每微升201~1 700个,均值每微升473.15个。HIV感染后,不同年份组间CD4细胞计数无显著性差异(P>0.05);不同年龄和性别组间CD4细胞计数有显著性差异(P<0.05);轻度以上免疫缺陷率88.24%,不同年份组间免疫缺陷无显著性差异(P>0.05);不同年龄和性别组间免疫缺陷有显著性差异(P<0.05)。结论HIV感染者中男性明显超过了女性,尤其是男性同性伴侣者。感染HIV血液细胞和生化检测指标均会出现不同程度的异常,CD4+T淋巴细胞水平、免疫缺陷程度与性别、年龄有关,与感染年份无关。应密切关注高危人群及高危传播途径,广泛开展线上或线下的健康宣教,推广安全套的使用,提高患者自身防护意识,减少艾滋病传播。Objective To analyze the multi-index results of the newly found hiv-infected persons in Hebei port from 2012 to 2022,and to provide evidence for HIV/AIDS prevention and control.Methods Venous blood samples were collected from newly found HIV antibody positive patients and healthy controls,blood routine test,se-rum total protein,ALT,AST,BUN,creatinine,lactate dehydrogenase,calcium,Phosphorus,ESR,CD4,CD8,CD4/CD8,immunoglobulin and complement C3 were measured and statistical analysis of the test results.Results Among the 68 HIV infected persons,the number of male was more than that of female.The infection rate of 30-50 years old group was relatively high,sexual contact continues to be the most common mode of infection among per-sons entering or leaving the country.The abnormal rate of erythrocyte sedimentation rate was 100%,the abnormal rate of CD4/CD8 was 91.18%,and the phenomenon of T cell subcohorte inversion was obvious.The abnormal rate of total protein(76.47%),ALT(72.06%)and AST(77.94%)was more than 70%.The absolute number of CD4 cells ranged from 201 to 1700/μl,with a mean of 473.15/μl.After HIV infection,there was no significant difference in CD4 lymphocyte count between the groups of different years(P>0.05),but there was significant difference in CD4 lymphocyte count between different sex and age groups(P<0.05).The rate of mild immune deficiency was 88.24%,and there was no significant difference between the groups of different years(P>0.05),but there was significant dif-ference between the groups of different sex and age(P<0.05).Conclusion The prevalence of HIV infection in male is higher than that in female,especially in male same-sex partners.The level of CD4+T lymphocyte and the degree of immunodeficiency were related to sex and age,but not to the year of infection.We should pay close atten-tion to the high-risk group and the high-risk transmission route,widely carry out on-line or off-line health educa-tion,promote the use of condoms,improve patients'self-protection awareness,reduce the spread of AIDS

关 键 词：出入境人员 新发 HIV感染者 CD4+T淋巴细胞 免疫缺陷 

分 类 号：R392.11[医药卫生—免疫学]