大黄的主要化学成分及药理作用研究进展  

Research progress on main chemical constituents and pharmacological effects of Radix et Rhizoma Rhei

作　　者：肖先 李春燕[1,2] 薛金涛 XIAO Xian;LI Chunyan;XUE Jintao(School of Pharmacy,Xinxiang Medical University,Xinxiang 453003,Henan Province,China;Biological and Basic Medical Experimental Teaching Center,Sanquan College of Xinxiang Medical University,Xinxiang 453003,Henan Province,China)

机构地区：[1]新乡医学院药学院,河南新乡453003 [2]新乡医学院三全学院生物与基础医学实验教学中心,河南新乡453003

出　　处：《新乡医学院学报》2024年第5期486-490,496,共6页Journal of Xinxiang Medical University

基　　金：河南省重点研发与推广专项(河南省科技攻关计划)(编号:222102310566)。

摘　　要：大黄是我国大宗中药材之一,其药用历史悠久且临床应用广泛。大黄具有泻下攻积、清热泻火、凉血解毒、逐瘀通经和利湿退黄等功效,其主要化学成分包括蒽醌类、蒽酮类、二苯乙烯类、苯丁酮类、多糖类、鞣质类和挥发油等,药理作用主要包括泻下、抗炎、抗肿瘤、调节血脂、肾保护、肝保护及抗血管生成等。本文对大黄的主要化学成分及现代药理作用进行概括总结,旨在为大黄的临床使用及药理作用研究提供参考依据。Radix et Rhizoma Rhei is one of the major Chinese medicinal herbs,with a long medicinal history and extensive clinical application.It has the effects of purgation,clearing heat and fire,cooling blood and detoxifying,expelling stasis and channeling meridian,diuresis and retreating yellow,etc.Its chemical constituents mainly include anthraquinones,anthrones,stilbenes,benzophenones,polysaccharides,tannins,and volatile oils.The pharmacological effects mainly include purgation,anti-inflammation,anti-tumor,lipid regulation,renal protection,liver protection,and anti-angiogenesis.This article summarizes the main chemical constituents and modern pharmacological effects of Radix et Rhizoma Rhei,aiming to provide a reference for the research of clinical use and pharmacological effects of Radix et Rhizoma Rhei.

关 键 词：大黄 化学成分 药理作用 

分 类 号：R932[医药卫生—生药学]