Effect of mechanical stresses on degradation behavior of high-purity magnesium in bone environments  

作　　者：Yan Yao Jie Xia Lizhen Wang Yuanming Gao Xili Ding Chao Wang Yubo Fan 

机构地区：[1]Key Laboratory of Biomechanics and Mechanobiology(Beihang University),Ministry of Education,Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science and Medical Engineering,School of Engineering Medicine,Beihang University,Beijing 100083,China

出　　处：《Journal of Materials Science & Technology》2024年第4期252-261,共10页材料科学技术（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.T2288101,12172034,U20A20390,11827803,12202036);the Beijing Municipal Natural Science Foundation(No.7212205);the 111 Project(No.B13003);the Fundamental Research Funds for the Central Universities.

摘　　要：High-purity(HP)magnesium(Mg)has emerged as a promising biomaterial for supporting functional bone tissue.Our previous study found that mechanical stresses and the surrounding fibrotic tissue(subcuta-neous)both play crucial roles in the degradation of HP Mg.However,due to challenges in the degradation and regeneration process in vivo,it remains unclear how stress affects HP Mg degradation in bone en-vironments,limiting its further application.In this study,novel loading devices were designed and the effects of tensile and compressive stresses on HP Mg degradation in vivo and in vitro bone environments were quantitatively analyzed.In addition,bone osteointegration around HP Mg was explored preliminar-ily.Tensile stress increases the degradation rate of HP Mg in vivo and in vitro.HP Mg degradation in vivo is more sensitive to stress factors than in vitro,but the sensitivity decreases with corrosion time.The volume loss rate of HP Mg is multilinear with the applied stress and degradation time.The volume of bone tissue surrounding HP Mg is larger in the no-stress group compared to the stressed groups,which is more pronounced with increasing implantation time.These results provide valuable insights for optimiz-ing the design of HP Mg-based implants considering load conditions.This will help to achieve a balance between the degradation rate of the implant and the regeneration rate of the surrounding bone.

关 键 词：High-purity magnesium Quantitative stresses Degradation Bone environments In vivo and in vitro 

分 类 号：TG172.9[金属学及工艺—金属表面处理]