住院患者药物不良反应及合理用药干预对策探讨  

Exploration of Adverse Drug Reactions and Rational Medication Intervention Strategies in Hospitalized Patients

作　　者：周永梅 Zhou Yongmei(Pharmacy Department,Kaili City First People’s Hospital,Kaili,Guizhou 556000)

机构地区：[1]贵州省凯里市第一人民医院药剂科,贵州凯里556000

出　　处：《科技与健康》2024年第6期53-56,共4页Technology and Health

摘　　要：为制订合理的用药干预对策,对临床安全用药提供参考,选取贵州省凯里市第一人民医院2021年1月—2022年1月收治的114例住院患者为研究对象,并针对其用药后发生药物不良反应(adverse drug reactions,ADRs)的情况进行分析。根据114例住院患者ADRs报告,统计ADRs类型、给药途径、发生ADRs的药品种类、ADRs累及的系统/器官等。通过统计的数据分析,制订合理的用药干预对策,并对干预前后患者的生活质量与用药依从性进行比较。数据显示,中老年患者更容易发生ADRs,占75.44%;静脉滴注发生ADRs现象最常见,占51.75%;ADRs涉及药品种类以抗感染类药物最多,占23.68%;累及系统/器官最多的为皮肤及其附件,占32.45%。进行合理用药干预后患者的生活质量与用药依从性较干预前显著提高(P<0.05)。研究结果表明,住院患者自身抵抗力较弱,一般采取静脉滴注给药及多联合用药,治疗过程中更易发生ADRs,临床上需予以重视并进行积极的用药干预,为安全有效的治疗提供保障。To develop reasonable medication intervention strategies and provide reference for clinical safe medication,114 hospitalized patients admitted to Kaili City First People’s Hospital from January 2021 to January 2022 were selected as the research subjects,and their occurrence of adverse drug reactions(ADRs)after medication was analyzed.According to the ADR reports of 114 hospitalized patients,the types of ADRs,routes of administration,types of drugs involved in ADRs,and systems/organs affected by ADRs were statistically analyzed.Through statistical data analysis,develop reasonable medication intervention strategies,and compare the quality of life and medication compliance of patients before and after intervention.Data shows that middle-aged and elderly patients are more prone to ADRs,accounting for 75.44%;Intravenous infusion is the most common occurrence of ADRs,accounting for 51.75%;ADRs involve the most types of drugs,with anti-infective drugs accounting for 23.68%;The most affected system/organ is the skin and its attachments,accounting for 32.45%.After reasonable medication intervention,the quality of life and medication adherence of patients significantly improved compared to before intervention(P<0.05).The research results indicate that hospitalized patients have weak self-resistance and are generally treated with intravenous infusion and multiple combination medications.ADRs are more likely to occur during the treatment process,and should be taken seriously and actively intervened with medication in clinical practice to provide assurance for safe and effective treatment.

关 键 词：住院患者 药物不良反应 合理用药干预对策 

分 类 号：R969.3[医药卫生—药理学]