基于壳聚糖/银离子的可逆温敏水凝胶的制备与性能  

Preparation and properties of reversible thermoresponsive hydrogels based on chitosan and silver ion

作　　者：徐世宽 张弘妹 戚鹏飞 曹张军[2] 邢彦军[1] XU Shikuan;ZHANG Hongmei;QI Pengfei;CAO Zhangjun;XING Yanjun(College of Chemistry and Chemical Engineering,Donghua University,Shanghai 201620,China;College of Biological Science and Medical Engineering,Donghua University,Shanghai 201620,China)

机构地区：[1]东华大学化学与化工学院,上海201620 [2]东华大学生物与医学工程学院,上海201620

出　　处：《精细化工》2024年第5期1036-1042,共7页Fine Chemicals

摘　　要：以壳聚糖(CS)和AgNO_(3)为主要原料,通过CS与Ag^(+)的超分子络合作用制备了一系列可逆温敏CS-Ag水凝胶,采用FTIR、XRD、XPS、SEM和EDS对CS-Ag水凝胶的结构和化学状态进行了表征。结果表明,通过同时调节AgNO_(3)用量和体系pH可制备具有相同凝胶温度的CS-Ag水凝胶。当CS用量为0.60 g、AgNO_(3)用量为0.19 g、体系总体积为21 mL、保持水凝胶pH=4.24时,制备的CS-Ag-19水凝胶凝胶温度为50℃,具有最佳的热可逆性能,至少可循环相变5次,具有室温避光保存5个月的稳定性,并表现出对大肠杆菌良好的抗菌性能。CS-Ag-19的溶胶-凝胶转换是由CS的氨基在不同温度下的超分子相互作用控制,H^(+)和Ag^(+)在温度、浓度变化的驱动下,对游离氨基的竞争反应(质子化和络合作用)之间的平衡关系使水凝胶具有温敏可逆性。CS-Ag-19水凝胶的可注射和温敏凝胶性能使其具有作为水凝胶抗菌敷料的应用潜力。A series reversible thermoresponsive chitosan(CS)-Ag hydrogels were prepared from supermolecule complexation of CS with Ag^(+)of AgNO_(3),and characterized by FTIR,XRD,XPS,SEM and EDS for structure and chemical state analyses.The results showed that the CS-Ag hydrogels with the same gelation temperature could be obtained by adjusting the AgNO_(3)amount and pH simultaneously.CS-Ag-19 hydrogel,prepared under conditions of CS amount 0.60 g,AgNO_(3)amount 0.19 g,total volume 21 mL,and hydrogel pH 4.24,exhibited the best thermoreversible property,with cycle phase transformation for at least 5 times and stability for 5 months when stored at room temperature away from light.Moreover,the hydrogel displayed good antibacterial performance against Escherichia coli.The reversible thermoresponsiveness of CS-Ag hydrogel was controlled by supramolecular interactions among amino group at different temperatures.The equilibrium relationship between H^(+)and Ag^(+),driven by changes in temperature and concentration,and competitive reactions(protonation and complexation)against free amino groups made the hydrogel temperature sensitive and reversible.The injectability and thermo sensitivity of CS-Ag-19 made it promising as antibacterial dressing.

关 键 词：可逆温敏水凝胶 壳聚糖 银离子 抗菌性 可注射性 功能材料 

分 类 号：TQ630[化学工程—精细化工] TQ427.26