生殖细胞减数分裂端粒挂膜分子机制概述  

Summary of mechanisms under telomere-nuclear attachment in meiosis of germ cells

作　　者：马阿妮 刘东腾 张键[2] MA A-ni;LIU Dong-teng;ZHANG Jian(Shenzhen Key Laboratory of Fertility Regulation,Center of Assisted Reproduction and Embryology,The University of Hong Kong-Shenzhen Hospital,Shenzhen 518053;Shenzhen Key Laboratory of Metabolic Health,Center for Energy Metabolism and Reproduction,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055)

机构地区：[1]深圳市生育调控重点实验室,香港大学深圳医院生殖医学中心,深圳518053 [2]深圳市代谢健康重点实验室,能量代谢与生殖研究中心,中国科学院深圳先进技术研究院,深圳518055

出　　处：《生殖医学杂志》2024年第5期676-681,共6页Journal of Reproductive Medicine

基　　金：深圳市孔雀计划(KQTD20190929172749226);国家自然科学基金(82301907);深圳市科技计划资助(JCYJ20220818101218040);深圳市代谢健康重点实验室(ZDSYS20210427152400001)。

摘　　要：减数分裂是生殖细胞形成配子的分裂方式,染色体端粒正确锚定在核膜上是这一重要生理过程顺利进行的前提。蛋白与蛋白的相互作用使端粒悬挂在生殖细胞的核膜上,以保证减数第一次分裂前期中染色体配对、联会和同源重组的正确进行。本文对目前已知的减数分裂端粒挂膜相关蛋白及复合物,包括端粒保护蛋白复合物(Shelterin)、减数分裂特异的核骨架和细胞质骨架连接复合物(LINC)、内核膜相关的TERB1-TERB2-MAJIN(TTM)复合物,以及SPDYA-CDK2复合体的结构和功能方面进行概括及综述。Germ cells produce gametes through meiosis,and the telomere-nuclear envelop(NE)attachment is the prerequisite for this vital physiological process.The proteins interact with each other to ensure the telomere-NE attachment and facilitate proper chromosome pairing,synapsis and homologous recombination during meiosis prophase I.In this paper,we will summarize findings about structures and functions of telomere-NE attachment related proteins and their complex,including Shelterin complex,meiosis specific linker of the nucleoskeleton and cytoskeleton complex(LINC),inner membrane related TERB1-TERB2-MAJIN(TTM)complex,and the SPDYA-CDK2 complex.

关 键 词：减数分裂 染色体 端粒 端粒挂膜 非梗阻性无精子症 

分 类 号：R339.2[医药卫生—人体生理学]