端粒在获得性再生障碍性贫血克隆演化中的作用  

Role of Telomere in Clonal Evolution of Acquired Aplastic Anemia--Review

作　　者：李丹妮 温贤浩[1] LI Dan-Ni;WEN Xian-Hao(Hematology and Oncology Department,Children's Hospital of Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorders,National Clinical Research Center for Child Health and Disease,China International Science and Technology Cooperation Base of Child Development and Critical Disorders,Chongqing Key Laboratory of Pediatrics,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院血液肿瘤科,儿童发育疾病研究教育部重点实验室,国家儿童健康与疾病临床医学研究中心,儿童发育重大疾病国家国际科技合作基地,儿科学重庆市重点实验室,重庆400014

出　　处：《中国实验血液学杂志》2024年第3期962-964,共3页Journal of Experimental Hematology

基　　金：重庆市科卫联合医学科研项目(2021MSXM065)。

摘　　要：1/3获得性再生障碍性贫血患者端粒长度存在缩短,且端粒越短的患者病程越长、越易复发、总体生存率越低,出现克隆演化的概率越大。端粒长度受到多方面因素的影响,包括端粒酶活性、端粒酶相关基因、端粒调控蛋白等。端粒缩短导致遗传信息不稳定,使获得性再生障碍性贫血患者出现克隆演化的概率增加。本文就端粒在获得性再生障碍性贫血克隆演化中的作用及影响端粒长度因素的最新研究进展作一综述。Studies have found that 1/3 patients with acquired aplastic anemia have shortened telomere length,and the shorter the telomere,the longer the disease course,the more prone to relapse,the lower the overall survival rate,and the higher the probability of clonal evolution.The regulation of telomere length is affected by many factors,including telomerase activity,telomerase-related genes,telomere regulatory proteins and other related factors.Telomere shortening can lead to genetic instability and increases the probability of clonal evolution in patients with acquired aplastic anemia.This article reviews the role of telomere in the clonal evolution of acquired aplastic anemia and factors affecting telomere length.

关 键 词：端粒 获得性再生障碍性贫血 克隆演化 

分 类 号：R556.5[医药卫生—血液循环系统疾病]