糖蛋白过敏原N-糖链与过敏的相关性研究  

Allergy Associated With N-glycans on Glycoprotein Allergens

作　　者：张瑜芯 刘瑞杰 张绍兴 袁舒颖 陈妍雯 叶以琳 林谦阁 芦鑫荣 童永亮 陈力 孙桂芹[1] ZHANG Yu-Xin;LIU Rui-Jie;ZHANG Shao-Xing;YUAN Shu-Ying;CHEN Yan-Wen;YE Yi-Lin;LIN Qian-Ge;LU Xin-Rong;TONG Yong-Liang;CHEN Li;SUN Gui-Qin(School of Medical Technology and Information Engineering,Zhejiang Chinese Medical University,Hangzhou 310053,China;Department of Clinical Laboratory,Jiaxing Maternity and Child Health Care Hospital,Jiaxing 314009,China;Department of Central Laboratory,Renji Hospital Shanghai Jiaotong University School of Medical,Ningbo Hangzhou Bay Hospital,Ningbo 315336,China;Department of Medical Microbiology and Parasitology,Key Laboratory of Medical Molecular Virology of Ministries of Education and National Health Committee,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China)

机构地区：[1]浙江中医药大学医学技术与信息工程学院,杭州310053 [2]嘉兴妇幼保健院检验科,嘉兴314009 [3]上海交通大学医学院附属仁济医院宁波医院,宁波市杭州湾医院,中心实验室,宁波315336 [4]复旦大学基础医学院病原生物学系,医学分子病毒学教育部/卫生健康委员会重点实验室,上海200032

出　　处：《生物化学与生物物理进展》2024年第5期1023-1033,共11页Progress In Biochemistry and Biophysics

基　　金：浙江中医药大学-先思达生物科技有限公司合作项目(2023-HT-275);浙江省马丽俐名老中医专家传承工作室(GZS2021019)资助。

摘　　要：糖蛋白是一种含有寡糖链的蛋白质,糖链与蛋白质之间以共价键相连。N-糖蛋白为常见过敏原之一,主要来源于食物、吸入物、昆虫毒素等,能够引起过敏反应。N-糖蛋白过敏原的N-糖链结构影响过敏原与IgE的结合,影响抗原提呈细胞(APC)对过敏原的识别和提呈。本文在介绍与过敏相关的N-糖蛋白、常见N-糖蛋白过敏原的N-糖链结构及与过敏相关的糖基化酶的基础上,进一步分析过敏原N-糖链影响过敏的机制,为临床预防与治疗过敏性疾病提供新的思路。Protein as the allergens could lead to allergy.In addition,a widespread class of allergens were known as glycans of N-glycoprotein.N-glycoprotein contained oligosaccharide linked by covalent bonds with protein.Recently,studies implicated that allergy was associated with glycans of heterologous N-glycoprotein found in food,inhalants,insect toxins,etc.The N-glycan structure of N-glycoprotein allergen has exerted an influence on the binding between allergens and IgE,while the recognition and presentation of allergens by antigen-presenting cells(APCs)were also affected.Some researches showed that N-glycan structure of allergen was remodeled by N-glycosidase,such as cFase I,gpcXylase,as binding of allergen and IgE partly decreased.Thus,allergic problems caused by N-glycoproteins could potentially be solved by modifying or altering the structure of N-glycoprotein allergens,addressing the root of the issue.Mechanism of N-glycans associated allergy could also be elaborated through glycosylation enzymes,alterations of host glycosylation.This article hopes to provide a separate insight for glycoimmunology perspective,and an alternative strategy for clinical prevention or therapy of allergic diseases.

关 键 词：过敏反应 N-糖基化 N-糖链结构 糖基化相关酶 过敏机制 

分 类 号：R392.8[医药卫生—免疫学] Q53[医药卫生—基础医学]