中药抑制缺氧诱导因子-1α相关信号通路的抗肿瘤作用研究进展  

Research Progress on Anti-tumor Effect of Traditional Chinese Medicine by Inhibiting HIF-1α-related Signaling Pathways

作　　者：毛梦婷 许尤琪[2] 董孟佳 李伟良[2] 唐杰[2] MAO Mengting;XU Youqi;DONG Mengjia;LI Weiliang;TANG Jie(Nanjing University of Chinese Medicine,Nanjing 210029,China;The Second Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210017,China)

机构地区：[1]南京中医药大学,南京210029 [2]南京中医药大学第二附属医院,南京210017

出　　处：《世界中医药》2024年第4期600-605,共6页World Chinese Medicine

基　　金：国家自然科学基金项目(82272671);江苏省中医药管理局科技发展计划项目(YB2020023);江苏省研究生科研与实践创新项目(SJCX22_0818);南京中医药大学第二附属医院传承工作室项目:许尤琪名老中医工作室(2021年)。

摘　　要：缺氧是实体肿瘤的常见特征,缺氧微环境可引起缺氧诱导因子-1(HIF-1)过表达。HIF-1α是缺氧应答中至关重要的转录调控因子,在各类肿瘤组织中均过表达,其在肿瘤细胞的增殖、侵袭转移、血管生成、糖酵解和免疫中发挥重要作用并参与多种转导通路。因此,HIF-1α作为治疗实体肿瘤的潜在靶点,颇有应用前景。相较于HIF-1α抑制剂存在高毒性、低效性的问题,中药具有多靶点、低毒性、高耐受性等优势,在肿瘤治疗中有广泛的应用前景。Hypoxia is a common feature of solid tumors,and the hypoxia microenvironment can cause overexpression of hypoxia inducible factor-1(HIF-1).HIF-1αis a key transcriptional regulatory factor in hypoxia response,which is highly expressed in all kinds of tumor tissue.It plays an important role in tumor cell proliferation,invasion and metastasis,angiogenesis,glycolysis,and immunity and participates in a variety of transduction pathways.Therefore,HIF-1αhas a promising prospect as a potential target for the treatment of solid tumors.Compared with HIF-1αinhibitors,with high toxicity and low efficiency,traditional Chinese medicine(TCM)has the advantages of multiple targets,low toxicity,and high tolerance,so it has a wide application prospect in tumor therapy.

关 键 词：缺氧诱导因子-1Α 中药 肿瘤 信号通路 缺氧 机制 

分 类 号：R273[医药卫生—中西医结合]