基于超声子宫内膜容受性参数和淋巴细胞免疫表型对复发性流产再孕早期流产的影响因素分析  

Influencing factors of early miscarriage after recurrent spontaneous abortion based on ultrasound endome⁃trial receptivity parameters and lymphocyte immunophenotype

作　　者：戴小颖[1] 沈亚[2] 谭小方[2] DAI Xiaoying;SHEN Ya;TAN Xiaofang(Department of Ultrasound,Nantong Maternal and Child Health Hospital,Nantong 226001,China;不详)

机构地区：[1]南通市妇幼保健院超声科,江苏南通226001 [2]南通市妇幼保健院生殖医学中心,江苏南通226001

出　　处：《实用医学杂志》2024年第10期1402-1406,共5页The Journal of Practical Medicine

基　　金：江苏省卫生健康委医学科研立项项目(编号:Z2020076)。

摘　　要：目的基于超声子宫内膜容受性参数和淋巴细胞免疫表型探究不明原因复发性流产患者再妊娠后妊娠结局的影响因素。方法选择2022年4-8月南通市妇幼保健院收治的不明原因复发性自然流产再次妊娠患者166例。根据妊娠结局分为成功分娩组和再次流产组,检测子宫内膜容受性参数及外周血T淋巴细胞,筛查不明原因复发性流产患者再次妊娠流产的影响因素。结果166例患者中成功分娩102例(61.45%),再次流产64例(38.55%)。成功分娩组患者的子宫内膜厚度、内膜容积、血管化血流指数(VFI)均高于再次流产组(P<0.05)。成功分娩组患者的CD4^(+)、CD4^(+)/CD8^(+)低于再次流产组(P<0.05)。CD4^(+)、CD4^(+)/CD8^(+)是妊娠失败的危险因素(P<0.05),子宫内膜厚度、内膜容积、VFI是妊娠失败的保护因素(P<0.05)。结论不明原因复发性流产患者再妊娠的妊娠结局与子宫内膜厚度、内膜容积、VFI、CD4^(+)、CD4^(+)/CD8^(+)有关。Objective To explore the influencing factors of pregnancy outcome after re-pregnancy in patients with unexplained recurrent spontaneous abortion based on ultrasound endometrial receptability parameters and lymphocyte immunophenotype.Methods A total of 166 re-pregnant patients with unexplained recurrent spon⁃taneous abortion admitted to Nantong Maternal and Child Health Hospital from April to August 2022 were included in the study.According to the pregnancy outcome,the patients were divided into the delivery group and the abortion group.The endometrial receptability parameters and peripheral blood T lymphocytes were detected to screen the influencing factors of abortion.Results Among 166 patients,102 cases(61.45%)had successful delivery and 64 cases(38.55%)had abortion again.The delivery group showed thicker endometrial thickness,larger endometrial volume,and higher VFI,but lower CD4^(+)and CD4^(+)/CD8^(+)compared to the abortion group(P<0.05).CD4^(+)and CD4^(+)/CD8^(+)were observed to be the risk factors for pregnancy failure(P<0.05),and endometrial thickness,endo⁃metrial volume,and vascularized flow index(VFI)were found to be the protective factors for pregnancy failure(P<0.05).Conclusion The pregnancy outcome of patients with unexplained recurrent spontaneous abortion is related to endometrial thickness,endometrial volume,VFI,CD4^(+),and CD4^(+)/CD8^(+).

关 键 词：复发性流产 不明原因 妊娠早期 

分 类 号：R714.21[医药卫生—妇产科学]