广州地区鼻咽癌筛查人群EB病毒感染状况与影响因素研究  

EBV infection and influencing factors of nasopharyngeal carcinoma screening population in Guangzhou

作　　者：窦前 张玉振 周勇 DOU Qian;ZHANG Yuzhen;ZHOU Yong(Guangzhou Cadre and Talent Health Management Center(the Eleventh People′s Hospital of Guangzhou),Guangzhou 510530,China)

机构地区：[1]广州市干部和人才健康管理中心(广州市第十一人民医院),广州510530

出　　处：《实用医学杂志》2024年第10期1440-1444,共5页The Journal of Practical Medicine

基　　金：广州市科技计划项目(编号:201904010153)。

摘　　要：目的研究广州地区鼻咽癌筛查人群中爱泼斯坦-巴尔病毒(EBV)的感染状况,并对EBV感染的影响因素进行分析。方法收集2021年1~12月在广州市干部和人才健康管理中心进行EBV抗体VCA-IgA和NA1-IgA检测的鼻咽癌筛查人群的资料,年龄20岁以上,了解EBV感染状况,并通过logistic回归分析其感染情况及影响因素。结果共收集研究对象55311例,其中男35429例(64.05%),女19882例(35.95%),总体EBV感染率为8.0%,不同性别的差异无统计学意义(P>0.05);随着年龄增加,EBV感染率增高,20~39岁感染率7.07%,40~59岁感染率7.86%,60~79岁感染率10.11%,≥80岁感染率10.99%(χ^(2)=85.487,P<0.01),logistic回归分析结果表明:随着年龄的增长,感染EBV的风险显著增加,40~59岁人群感染EBV的风险较20~39岁人群高10.6%(OR=1.106,95%CI:1.028~1.190);60~79岁人群感染EBV的风险较20~39岁人群高42.2%(OR=1.422,95%CI:1.288~1.569);80岁以上人群感染EBV的风险较20~39岁人群高53.1%(OR=1.531,95%CI:1.230~1.906),有高血压病史的感染风险较无高血压者高10.5%(OR=1.105,95%CI:1.003~1.218);是否有糖尿病史不会显著影响EBV感染结果(P>0.05)。结论广州地区EBV总体感染率为8.00%,年龄增加和高血压病史是EBV感染的危险因素,相关部门需要进一步加强EBV易感人群的筛查与防控。Objective To study EBV infection in nasopharyngeal carcinoma screening population in Guangzhou and analyze the influencing factors.Methods The data of individuals(aged 20 years and above)having EBV antibody of VCA-IgA and NA1-IgA test in Guangzhou Cadre and Talent Health Management Centerwere collected.Current status of EBV infection was studied and its influencing factors were analyzed by logistic regression analysis.Results A total of 55311 subjects were screened,including 35429 males(64.05%)and 19,882 females(35.95%).The overall EBV infection rate was 8.00%.There was no significant differences in the infection rate between different sex groups(P>0.05).The infection rate of EBV increased with age,with infection rate of 7.07%in individuals aged 20~39 years,7.86%in those aged 40~59 years,10.11%in those of 60~79 years old,and 10.99%in those aged≥80 years,showing statistical significance(χ^(2)=85.487,P<0.01).Logistic regression analysis showed that EBV infection risk increased significantly with advancing age.The odds of EBV infection in individuals aged 40~59 years were 10.6%higher compared to those aged 20~39 years(OR=1.106,95%CI:1.028~1.190).The odds of EBV infection in individuals aged 60~79 years were 42.2%higher compared to those aged 20~39 years(OR=1.422,95%CI:1.288~1.569).Furthermore,the odds of EBV infection in individuals aged≥80 years were 53.1%higher compared to those aged 20~39 years(OR=1.531,95%CI:1.230~1.906).A prior diagnosis of hypertension significantly increased the odds of EBV infection(OR=1.105,95%CI:1.003~1.218).However,diabetes history exerted no influence on the outcome of EBV infection(P>0.05).Conclusions The overall infection rate of EBV in Guangzhou is 8.00%.Advanced age and hypertension history are the risk factors of EBV.The screening and prevention and control of EBV susceptible people should be strengthened.

关 键 词：鼻咽癌 爱泼斯坦-巴尔病毒感染 危险因素 

分 类 号：R373[医药卫生—病原生物学]