SA/AKP/PEG 4000神经导管的制备与表征  

Preparation and characterization of SA/AKP/PEG 4000 neural catheter

作　　者：丁铭飞 郭静 张一航 李政 田钧 DING Mingfei;GUO Jing;ZHANG Yihang;LI Zheng;TIAN Jun(School of Textile and Material Engineering,Dalian Polytechnic University,Dalian 116034,China)

机构地区：[1]大连工业大学纺织与材料工程学院,辽宁大连116034

出　　处：《大连工业大学学报》2024年第2期147-151,共5页Journal of Dalian Polytechnic University

基　　金：国家自然科学基金项目(51773024;51373027);辽宁省教育厅高校科研基金项目(J2040046)。

摘　　要：将神经导管植入损伤的神经组织处可促进神经恢复。受成本与技术的限制,湿法成型难以批量生产孔径大小和分布相对均匀的神经导管。为连续制备孔径大小及分布均匀的神经导管,以海藻酸钠、磷虾蛋白生物可降解材料作为基体,以PEG 4000作为致孔剂,通过低温湿法成型结合冷冻干燥方法制备了多孔神经导管支架材料,表征了材料的结构和性质。结果表明,PEG 4000有降低溶液的黏度、提高导管热稳定性的作用,导管截面具有蜂窝状孔洞结构,其孔径在10~20μm,最大孔隙率达到97%。导管为亲水材料,其吸液性能随PEG 4000质量分数呈先增大后减小的趋势,PEG 4000质量分数为30%~40%时导管的吸液性能达到1 417%。The implantation of nerve catheter into the injured nerve tissue can promote the recovery of nerve. However, it was difficult to large-scale produce neural catheters with relatively uniform pore size and distribution by wet molding method owing to the limitations of cost and technology. In order to continuously prepare nerve catheter with uniform pore size and distribution, porous nerve catheter scaffolds were prepared using biodegradable polymers of sodium alginate and krill protein as matrix and PEG 4000 as pore-inducing agent through the combination method of low temperature wet molding and freeze drying. Additionally, the structure and properties of the materials were characterized. The results showed that PEG 4000 could reduce the viscosity of solution and improve the thermal stability of the catheter. The cross section of the catheter exhibited a honeycomb structure with pore size from 10 to_(2)0 μm and a maximum porosity of 97%. The catheter was with hydrophilic property, and its absorbent performance firstly increased and then decreased with the increasing content of PEG 4000. The adsorption performance of the catheter was 1 417%, when the content of PEG 4000 ranged from 30% to 40%.

关 键 词：海藻酸钠 聚乙二醇 神经导管 低温凝固 

分 类 号：R318.08[医药卫生—生物医学工程] TB332[医药卫生—基础医学]