达格列净对2型糖尿病减轻肾损害及炎症作用的临床观察  

The Clinical Observation of Dapagaliflozin on Reducing Renal Damage and Inflammation in Type 2 Diabetes

作　　者：王煜 周荣 刘珊 WANG Yu;ZHI Rong;LIU Shan(Department of Basic Medicine Science,Yueyang Vocational Technical College,Yueyang,Hunan 414000;Internal Medicine Department,Dongmaoling Community Medical Service Center,Yueyang,Hunan 414000;Endocrine Department,Yueyang Centre Hospital,Yueyang,Hunan 414000)

机构地区：[1]岳阳职业技术学院基础医学部,湖南岳阳414000 [2]岳阳市东茅岭社区医疗服务中心内科,湖南岳阳414000 [3]岳阳市中心医院内分泌科,湖南岳阳414000

出　　处：《岳阳职业技术学院学报》2024年第2期75-78,共4页Journal of Yueyang Vocational and Technical College

摘　　要：目的 观察达格列净对早期2型糖尿病肾病(DN)患者肾功能和尿微量白蛋白的影响,探讨其与患者血清促炎症因子变化的关系。方法 纳入30例初诊2型糖尿病、50例早期DN患者与30例正常对照(NGT)。2型糖尿病组和DN组口服达格列净治疗>12周,观察其疗效、肾功能和血清促炎症因子的变化。结果 治疗后,2型糖尿病组和DN组空腹血糖和糖化血红蛋白下降,体重和血压均有下降(P<0.05);两组的肾小球滤过率有所下降(P<0.05);DN组的尿白蛋白/肌酐比值降低(P<0.05);糖尿病患者较正常对照组血清促炎症因子增加,而治疗后单核细胞趋化因子-1、白细胞介素-6和肿瘤坏死因子-α水平降低(P<0.05)。结论 达格列净能改善早期DN患者的尿蛋白漏出,除降糖、降压和减重外,该作用可能与促炎症因子水平的降低直接有关。Objective:To investigate the effects of Dapagliflozin on renal functions and urine microalbumin in diabetic nephropathy(DN) patients,and discuss the association between the effects and serum pro-inflammatory cytokines level.Methods:Thirty patients with new onset type 2 diabetes mellitus and 50 patients with diabetic nephropathy were treated with dapagliflozin for above 12 weeks.Thirty healthy subjects were involved in as normal control.The clinical effects,renal functions and serum pro-inflammatory cytokines were analyzed.Results:After 8 weeks treatment,the FBG and HbA1c in the type 2 diabetes mellitus and DN groups decreased(P<0.05).The body weight and blood pressures also reduced.The values of eGFR decreased in the two groups(P<0.05).The level of the urinary albumin/creatinine ratio(UACR) significantly decreased in DN group(P<0.05).The serum pro-inflammatory cytokines levels increased in type 2 diabetes mellitus patients.The levels of serum MCP‐1,IL‐6,and TNF‐α significantly reduced after dapagliflozin therapy(P<0.05).Conclusion:Dapagliflozin can ameliorate the leakage of urinary albumin in DN patients,and in addition to glucose reduction,blood pressure reduction,and weight loss,this effect may be directly related to a reduction in pro-inflammatory factor levels.

关 键 词：达格列净 糖尿病肾病 促炎症因子 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]