A Single-Fluorophore Multicolor Molecular Sensor That Visually Identifies Organic Anions Including Phosphates  

作　　者：Zezhou Zong Qi Zhang Da-Hui Qu 

机构地区：[1]Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center,School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai 200237

出　　处：《CCS Chemistry》2024年第3期774-782,共9页中国化学会会刊（英文）

基　　金：supported by the National Natural Science Foundation of China(grant nos.22220102004 and 22025503);Shanghai Municipal Science and Technology Major Project(grant no.2018SHZDZX03);the Innovation Program of Shanghai Municipal Education Commission(grant no.2023ZKZD40);the Fundamental Research Funds for the Central Universities,the Programme of Introducing Talents of Discipline to Universities(grant no.B16017);Science and Technology Commission of Shanghai Municipality(grant no.21JC1401700);the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study(grant no.SN-ZJUSIAS-006).

摘　　要：Developing fluorescent sensors for small-molecule phosphates offers opportunities in optically detecting biorelevant reactions and events.However,it remains elusive how to identify phosphates from other anions,such as carboxylates and sulfates,because current synthetic phosphate receptors lack selectivity.Here we report the construction of a multicolor fluorescent sensor that can identify phosphates from other analogous anions.The key design principle is to take advantage of the highly sensitive conformation-dependent emissive wavelength of diphenyl-9,14-dihydrodibenzo[a,c]phenazine fluorophores to sense the minor structural differences between phosphates and other anions,for example,sulfates and carboxylates.The effect of structural factors such as spacer length and urea versus thiourea has been investigated by comparing the optical properties and binding affinities with the phosphate receptors.This strategy provides a simple and robust fluorescent sensing solution to optically analyze small-molecule phosphates with antiinterference performance.

关 键 词：fluorescent sensors PHOTOLUMINESCENCE host-guest chemistry supramolecular chemistry noncovalent bonds 

分 类 号：O62[理学—有机化学]