针刺配合翁沥通胶囊治疗良性前列腺增生的疗效观察  

Therapeutic observation of acupuncture plus Weng Li Tong capsules for benign prostatic hyperplasia

作　　者：刘永存[1] 赵会谢 刘国伟[1] LIU Yongcun;ZHAO Huixie;LIU Guowei(Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050051,China)

机构地区：[1]石家庄市中医院,石家庄050051

出　　处：《上海针灸杂志》2024年第5期549-554,共6页Shanghai Journal of Acupuncture and Moxibustion

基　　金：河北省中医药管理局科研计划项目(2020345)。

摘　　要：目的观察针刺配合翁沥通胶囊治疗良性前列腺增生的临床疗效及其对血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、前列腺特异性抗原(prostate specific antigen,PSA)水平的影响。方法将119例良性前列腺增生患者随机分为A组40例、B组38例及C组41例。A组采用针刺治疗,B组采用口服翁沥通胶囊治疗,C组采用针刺配合口服翁沥通胶囊治疗。观察3组治疗前后尿动力学各项指标[排尿后残余尿量(postvoid residual urine,PVR)、最大尿流率(maximum urine flow,Qmax)、最大逼尿肌压力]、国际前列腺症状评分(international prostate symptom score,IPSS)、生活质量(quality of life,QOL)评分、中医证候(排尿困难、夜尿频数、腰膝酸软、小腹胀满)积分及实验室指标[血清TNF-α、PSA、白细胞介素-6(interleukin-6,IL-6)、表皮细胞生长因子(epidermal growth factor,EGF)水平]的变化情况,比较3组临床疗效。结果3组治疗后PVR、最大逼尿肌压力、I-PSS、QOL评分、各项实验室指标及中医证候积分均较同组治疗前显著降低,Qmax均显著升高,差异均具有统计学意义(P<0.05)。C组治疗后PVR、最大逼尿肌压力、I-PSS、QOL评分、各项实验室指标及中医证候积分均明显低于A组和B组,Qmax均明显高于A组和B组,差异均具有统计学意义(P<0.05)。A组治疗后各项指标与B组比较,差异均无统计学意义(P>0.05)。C组总有效率为92.7%,明显高于A组的70.0%和B组的73.7%,差异均具有统计学意义(P<0.05)。结论针刺配合翁沥通胶囊治疗良性前列腺增生疗效确切,能降低患者TNF-α、PSA水平,改善其临床症状。Objective To observe the clinical efficacy of acupuncture plus Weng Li Tong capsules in treating benign prostatic hyperplasia(BPH)and its effects on serum levels of tumor necrosis factor-α(TNF-α)and prostate specific antigen(PSA).Method A total of 119 patients with BPH were randomly allocated to group A(40 cases),group B(38 cases),and group C(41 cases).Group A was treated with acupuncture,group B was prescribed oral Weng Li Tong capsules,and group C received acupuncture plus oral Weng Li Tong capsules.Before and after the treatment,the three groups were observed for changes in the urodynamic parameters[postvoid residual urine(PVR),maximum urine flow(Qmax),and maximum detrusor pressure],international prostate symptom score(IPSS),quality of life(QOL)score,symptom score of traditional Chinese medicine(difficulty urinating,frequent nocturia,soreness and weakness in the low back and knees,and bloating in the lower abdomen),and laboratory indexes[serum TNF-α,PSA,interleukin-6(IL-6),and epidermal growth factor(EGF)].The clinical efficacy was compared among the three groups.Result After the treatment,the PVR,maximum detrusor pressure,IPSS score,QOL score,laboratory indexes,and traditional Chinese medicine symptom scores decreased,and the Qmax increased in the three groups,all showing statistical significance(P<0.05).After the intervention,the PVR,maximum detrusor pressure,IPSS score,QOL score,laboratory indexes,and traditional Chinese medicine symptom scores were significantly lower in group C than in groups A and B,and the Qmax was significantly higher in group C compared to the other two groups(P<0.05).There were no significant differences in the outcome measures between groups A and B after the intervention(P>0.05).The total effective rate was 92.7%in group C,higher than 70.0%in group A and 73.7%in group B,and the differences were statistically significant(P<0.05).Conclusion Acupuncture plus Weng Li Tong capsules can effectively treat BPH,down-regulating the TNF-αand PSA levels and improving clinical symptoms.

关 键 词：针刺疗法 前列腺增生 针药并用 肿瘤坏死因子-Α 前列腺特异性抗原 

分 类 号：R246.1[医药卫生—针灸推拿学]