H1抗组胺药在皮肤病治疗中的临床应用进展  

Advances in clinical application of H1 antihistamines in the treatment of skin diseases

作　　者：水心雨 李捷[1,2] SHUI Xinyu;LI Jie(Dermatology Hospital(Department of Dermatology),Xiangya Hospital,Central South University,Changsha 410008;National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院皮肤病医院(皮肤科),长沙410008 [2]国家老年疾病临床医学研究中心(湘雅医院),长沙410008

出　　处：《中南大学学报（医学版）》2024年第2期182-189,共8页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(82173424,81974476)。

摘　　要：组胺受体分为H_(1)、H_(2)、H_(3)、H_(4)这4种类型,分别介导不同的生理学效应且有其相应的拮抗剂,可用于多种疾病的预防和治疗。其中,H1抗组胺药是皮肤科的基础用药,被广泛应用于荨麻疹、特应性皮炎等多种疾病。近年来,新型抗组胺药不断出现,传统H1抗组胺药也被发现有新的潜在适应证,但抗组胺药的使用剂量仍存在差异。总结H1抗组胺药的作用机制、常用药物加倍剂量使用情况及潜在适应证,将为其临床实际应用提供重要的参考思路。Histamine receptors are classified into 4 types:H_(1),H_(2),H_(3),and H_(4),each mediating distinct physiological effects and possessing its corresponding antagonistshat that can be used for the prevention and treatment of various diseases.Among them,H1 antihistamines are the fundamental medications in dermatology and are widely used in many diseases such as urticaria and atopic dermatitis.In recent years,with the emergence of novel antihistamines and the discovery of new potential indications for traditional H1 antihistamines,the clinical application of antihistamines is facing new challenges.Further investigation of the novel mechanism for H1 antihistamines,the use of multiple doses of common drugs and potential indications will furnish vital insights for practical clinical application.

关 键 词：抗组胺药 荨麻疹 特应性皮炎 

分 类 号：R969[医药卫生—药理学]