极早产儿支气管肺发育不良相关肺高压合并动脉导管未闭9例预后分析  

Prognosis of very preterm infants with bronchopulmonary dysplasia-associated pulmonary hypertension and patent ductus arteriosus:An analysis of 9 cases

作　　者：锡洪敏[1] 马丽丽[1] 尹向云[1] 杨萍[1] 姜红[1] 李向红[1] XI Hongmin;MA Lili;YIN Xiangyun;YANG Ping;JIANG Hong;LI Xianghong(Department of Neonatology,The Affiliated Hospital of Qingdao University,Qingdao 266555,China)

机构地区：[1]青岛大学附属医院新生儿科,山东青岛266555

出　　处：《精准医学杂志》2024年第2期175-177,181,共4页Journal of Precision Medicine

基　　金：青岛大学附属医院“临床医学+X”科研项目(QDFY+2021013)。

摘　　要：目的分析9例支气管肺发育不良(bronchopulmonary dysplasia,BPD)相关肺高压(pulmonary hypertension,PH)合并动脉导管未闭(patent ductus arteriosus,PDA)极早产儿行PDA结扎术后的临床转归。方法回顾性分析9例合并PDA的BPD相关PH的极早产儿临床资料,所有患儿均给予PDA结扎手术,术后规律随访。结果手术治疗后7例患儿肺动脉压力降至正常,顺利脱机并出院,且后期规律门诊随访,均随访至2022年6月。随访者中最大者已4岁,所有患儿心脏超声示心脏结构及功能、肺动脉压力均正常,生长发育正常,无反复呼吸道感染发生。2例患儿死亡。结论合并PDA的BPD相关PH的极早产儿病情危重,在药物治疗失败的情况下,PDA适时结扎是改善预后的手段。Objective To investigate the clinical outcome of 9 very preterm infants with bronchopulmonary dysplasia(BPD)-associated pulmonary hypertension(PH)and patent ductus arteriosus(PDA)after PDA ligation.Methods A retrospective analysis was performed for the clinical data of 9 very preterm infants with BPD-associated PH and PDA,and all infants underwent PDA ligation and were followed up regularly after surgery.Results After surgical treatment,7 infants had normal pulmonary artery pressure and were discharged after successful ventilator weaning,and all these infants were regularly followed up to June 2022 at the outpatient service,among whom the oldest infant was aged 4 years;echocardiography showed that all infants had normal heart structure and function,pulmonary artery pressure,and growth and development,without recurrent respiratory infection.Two infants died.Conclusion Very preterm infants with BPD-associated PH and PDA often have critical situations,and in case of failed pharmacotherapy,timely PDA ligation is an important method to improve prognosis.

关 键 词：支气管肺发育不良 动脉导管未闭 肺动脉高压 结扎术 预后 婴儿 极度早产 

分 类 号：R725.622.9[医药卫生—儿科] R725.432[医药卫生—临床医学]