多指标结合AHP-CRITIC优化酸枣叶拌蒸酸枣仁炮制工艺  

Optimization of the Co-steaming Process of Semen Ziziphi Spinosae with Ziziphus Jujuba Leaf by Multi-index Combined with AHP-CRITIC Method

作　　者：程世赞 华悦 廉婧 聂紫璇 苏国明 常源 史辑[1,2] 贾天柱 CHENG Shi-zan;HUA Yue;LIAN Jing;NIE Zi-xuan;SU Guo-ming;CHANG Yuan;SHI Ji;JIA Tian-zhu(Liaoning University of Traditional Chinese Medicine School of Pharmacy,Dalian 110600,China;Liaoning Province Traditional Chinese Medicine Processing Technology Industry Innovation Center,Dalian 110600,China)

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600 [2]辽宁省中药炮制技术产业创新中心,辽宁大连116600

出　　处：《中国现代中药》2024年第4期677-684,共8页Modern Chinese Medicine

基　　金：国家自然科学基金项目(81874345);国家中医药管理局重点实验室研究领域的中医临床疗效提升项目(2100222179);沈阳市中青年科技创新人才支持计划项目(RC200174);2022年辽宁省自然科学基金资助面上项目(2022-MS-223)。

摘　　要：目的:采用正交设计结合层次分析法-客观赋权法(AHP-CRITIC)优化酸枣叶拌蒸酸枣仁的炮制工艺。方法:采用单因素试验优化辅料酸枣叶的加入倍量和蒸制时间,以酸枣叶的加入倍量和蒸制时间为因素,以斯皮诺素、6‴-阿魏酰斯皮诺素、酸枣仁皂苷A、白桦脂酸含量为评价指标进行综合加权评分,结合AHP-CRITIC优化酸枣仁的拌蒸工艺。结果:最佳拌蒸工艺为酸枣叶加入量是酸枣仁的4倍,1层酸枣叶1层酸枣仁交替平铺,上锅蒸制3 h。结论:多指标结合AHP-CRITIC优选酸枣仁拌蒸工艺合理可行,可为酸枣叶拌蒸酸枣仁炮制工艺的生产实践提供参考。Objective:To optimize the co-steaming process of Semen ziziphi spinosae with Ziziphus jujuba leaf based on orthogonal design and AHP-CRITIC method.Method:The single-factor experiment was applied to screen dosage range for Z.jujuba leaf and steaming time.Then,the co-steaming process was optimized by orthogonal design combined with AHP-CRITIC method with the contents of spinosin,6‴-ferulospinosin,jujuboside A,and betulinic acid as evaluation indexes and usage amount of Z.jujuba leaf and steaming time as influencing factors.Results:The optimal co-steaming process was to lay the Z.jujuba leaf and Semen ziziphi spinosae alternately,and the usage amount for Z.jujuba leaf was four times that of Semen ziziphi spinosae.The steaming time was 3 hours.Conclusion:The orthogonal design combined with AHP-CRITIC method was reasonable and feasible,and could provide a reference for the production practice of co-steaming process of Semen ziziphi spinosae with Z.jujuba leaf.

关 键 词：酸枣仁 酸枣叶 拌蒸工艺 正交设计 层次分析法-客观赋权法 

分 类 号：R283[医药卫生—中药学]