变异系数法-AHP复合加权联用TOPSIS模型优选白附片降毒增效炮制工艺  

Optimization of Processing Parameters of Baifupian for Detoxicating and Effect Enhancing by Combining Coefficient of Variation Method with AHP Composite Weighting and TOPSIS Model

作　　者：姚文燕 刘宸 张国彦 黄壮壮[4,5] 刘峰 YAO Wen-yan;LIU Chen;ZHANG Guo-yan;HUANG Zhuang-zhuang;LIU Feng(College of Pharmacy,Dali University,Dali 671000,China;National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China,The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry,The Ministry of Education,College of Life Sciences,Shaanxi Normal University,Xi'an 710119,China;Chenggu County Qunli Traditional Chinese Medicine Cooperative,Hanzhong 723000,China;Shaanxi International Business College,Xianyang 712046,China;Shaanxi Buchang Pharmaceutical Co.,Ltd.,Xi'an 710075,China)

机构地区：[1]大理大学药学院,云南大理671000 [2]陕西师范大学生命科学学院西北濒危药材资源开发国家工程实验室/药用资源与天然药物化学教育部重点实验室,陕西西安710119 [3]城固县群利中药材专业合作社,陕西汉中723000 [4]陕西国际商贸学院,陕西咸阳712046 [5]陕西步长制药有限公司,陕西西安710075

出　　处：《中国现代中药》2024年第4期685-694,共10页Modern Chinese Medicine

基　　金：陕西省重点研发项目(2020SF-326,2022SF-591)。

摘　　要：目的:运用变异系数法-层次分析法(AHP)复合加权联用TOPSIS优选白附片炮制工艺参数,为白附片规范化炮制提供参考。方法:以煮制时间、浸漂时间和蒸制时间为考察因素,以穷举寻根法开展试验设计,以苯甲酰新乌头原碱、苯甲酰乌头原碱、苯甲酰次乌头原碱、新乌头碱、次乌头碱、乌头碱、水分、灰分和胆巴残留量为评价指标,以变异系数法-AHP复合加权计算权重系数,通过TOPSIS模型优选白附片炮制工艺参数。结果:白附片最优炮制工艺参数为煮制20 min、浸漂48 h、蒸制3 h。结论:该工艺稳定、可行,可为白附片的规模化加工炮制提供参考。Objective:This study optimizes the processing parameters of Baifupian by combining the coefficient of variation method with the analytic hierarchy process(AHP)and TOPSIS model,so as to provide a reference for standardized processing of Baifupian.Methods:The factors of investigation are cooking time,soaking time,and steaming time,and the experiment design is carried out by enumeration method.The evaluation indexes are benzoylaconine,benzoylmesaconine,benzoylhypaconine,aconitine,mesaconitine,hypaconitine,water content,ash content,and brine residual.The coefficient of variation method and AHP composite weighting are used to calculate the weight coefficient.The processing parameters of Baifupian are optimized by using the TOPSIS model.Results:The optimal processing parameters of Baifupian are 20 min of cooking,48 h of soaking,and 3 h of steaming.Conclusion:The optimal processing parameters are stable and feasible,which can provide a reference for the large-scale processing of Baifupian.

关 键 词：白附片 炮制工艺 灰分 胆巴 单酯型生物碱 双酯型生物碱 

分 类 号：R282[医药卫生—中药学]