皮肤病血毒丸治疗寻常痤疮湿热夹毒证的临床观察  

Clinical Observation of Pifubing Xuedu Pill in Treating Acne Vulgaris with Syndrome of Damp-heat and Poisoning

作　　者：李红毅[1] 马万里 林欢儿 朱铭华[4] 许荣煌 王帅帅 杨志波[7] Li Hongyi;Ma Wanli;Lin Huan'er;Zhu Minghua;Xu Ronghuang;Wang Shuaishuai;Yang Zhibo(Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510000,Guangdong,China;The Affiliated Traditional Chinese Medicine Hospital of Guangzhou Medical University,Guangzhou 510000,Guangdong,China;Shenzhen Hospital of Beijing University of Traditional Chinese Medicine,Shenzhen 518000,Guangdong,China;GuangDong Second Traditional Chinese Medicine Hospital,Guangzhou 510000,Guangdong,China;TEYI Pharmaceutical Group Co.,Ltd,Guangzhou 510000,Guangdong,China;Guangzhou Hipower Pharmaceutical R&D Co.,Ltd,Guangzhou 510000,Guangdong,China;The Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha 410000,Hunan,China)

机构地区：[1]广东省中医院,广东广州510000 [2]广州医科大学附属中医医院,广东广州510000 [3]北京中医药大学深圳医院,广东深圳518000 [4]广东省第二中医院,广东广州510000 [5]特一药业集团股份有限公司,广东广州510000 [6]广州海博特医药科技有限公司,广东广州510000 [7]湖南中医药大学第二附属医院,湖南长沙410000

出　　处：《中国中西医结合皮肤性病学杂志》2024年第2期138-141,共4页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的观察皮肤病血毒丸治疗寻常痤疮湿热夹毒证的临床疗效与安全性。方法采用自身前后对照,对120例中度寻常痤疮患者给予皮肤病血毒丸单药治疗4周,疗程结束后随访4周,比较治疗前后患者皮损程度、生活质量的变化及不良反应等。结果治疗4周后,患者痤疮综合分级系统(GAGS)、皮肤病生活质量评分(DLQI)、研究者整体评估(IGA)、Cardiff痤疮伤残指数(CADI)、中医证候评分均较基线降低(P<0.001);疗程结束后随访第4周患者GAGS、DLQI、IGA、CADI、中医证候评分持续降低,相比基线差异有统计学意义(P<0.001)。研究过程中未发生不良反应。结论皮肤病血毒丸治疗寻常痤疮湿热夹毒证疗效确切,安全性较好。Objective In order to observe the clinical efficacy and safety of Pifubing Xuedu pill in treating acne vulgaris with syndrome of damp-heat and poisoning.Methods Totally 120 patients with moderate acne vulgaris were treated with Pifubing Xuedu pill for four weeks,and followed up for four weeks after treatment.The changes of skin lesions and quality of life were compared before and after treatment,and adverse events were observed.Results The global acne grading system(GAGS),dermatology life questionnaire index(DLQI),investigator global assessment(IGA),Cardiff acne disability index(CADI)and traditional Chinese medicine(TCM)syndrome scores of patients were significantly lower than those of baseline(P<0.001).After four weeks of treatment,the above scores were continued to decrease in the fourth week of follow-up after the end of treatment,and they were statistically lower compared with the baseline(P<0.001).No adverse reactions occurred during the study.Conclusion Pifubing Xuedu pill is effective and safe in treating acne vulgaris with syndrome of damp-heat and poisoning.

关 键 词：皮肤病血毒丸 寻常痤疮 湿热夹毒证 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]