^(18)F-FDG-(OAc)_(4)的合成及其在小鼠体内的生物分布  

Synthesis of ^(18)F-FDG-(OAc)_(4) and Its Bio-Distribution in Mice

作　　者：何正中 庞丁华 李宁[1] 张实来 杨洪 蒙小飞 杨志[1] 肖国有[1] HE Zhengzhong;PANG Dinghua;LI Ning;ZHANG Shilai;YANG Hong;MENG Xiaofei;YANG Zhi;XIAO Guoyou(Department of Nuclear Medicine(Guangxi Clinical Key Specialty),Guangxi Medical University Cancer Hospital,Nanning Guangxi 530021,China)

机构地区：[1]广西医科大学附属肿瘤医院核医学科(广西临床重点建设专科),广西南宁530021

出　　处：《中国医疗设备》2024年第5期26-30,共5页China Medical Devices

基　　金：广西科技计划项目重点研发计划(桂科AB19110015);广西生物靶向诊治研究重点实验室开放基金课题(GXSWBX202203,GXSWBX202204,GXSWBX202205);广西壮族自治区卫生健康委员会自筹经费科研课题(Z20190559,Z-A20220680,Z-A20220678);广西高校中青年教师科研基础能力提升项目(2023KY0084);广西医科大学青年科学基金项目(GXMUYSF202226,GXMUYSF202356)。

摘　　要：目的分析正电子药物合成器合成基氟-18标记的四乙酰脱氧葡糖[1,3,4,6-四乙酰基-O-2-^(18)F-2-脱氧-β-D葡萄糖,简称^(18)F-FDG-(OAc)_(4)]的稳定性和实用性。方法基于合成器及其合成工艺流程,进行^(18)F-FDG-(OAc)4合成产量和质量控制及其与氟-18标记的脱氧葡萄糖(2-[18F]-氟-2-脱氧-D-葡萄糖,简称18F-FDG)在小鼠体内的生物分布异同分析。结果连续3批合成^(18)F-FDG-(OAc)4的成功率为100%,产率分别为59.64%、60.61%、59.72%,产品溶液为无色透明溶液,放射性化学纯度≥96%(Rf值为0.8~0.9),放射性核纯度为100%。^(18)F-FDG-(OAc)_(4)与18F-FDG注入小鼠,后各个脏器的放射性摄取均无差别,差异无统计学意义(P>0.05)。结论正电子药物合成器合成^(18)F-FDG-(OAc)4的流程简单、便捷,合成成功率和合成产率较高,具有较强的稳定性和实用性。Objective To analyze the stability and practicality of the positron emission tomography drug synthesizer for the synthesis of ^(18)F-FDG-(OAc)4.Methods Based on the synthesizer and its synthetic process,the synthesis yield and quality control of ^(18)F-FDG-(OAc)_(4) were carried out,and the similarities and differences in biological distribution in mice between ^(18)F-FDG-(OAc)_(4) and ^(18)F-FDG were analyzed.Results The success rate of ^(18)F-FDG-(OAc)_(4) in 3 consecutive batches was 100%,and the yields were 59.64%,60.61%,and 59.72%,respectively.The product solution was colorless and transparent,with radioactive chemical purity was≥96%(Rf value was 0.8-0.9)and radioactive nuclear purity was 100%.There were no significant differences in the radioactive uptake of various organs after injecting ^(18)F-FDG-(OAc)_(4) and 18F-FDG into mice(P>0.05).Conclusion The synthesizer provides a simple and convenient process for the synthesis of ^(18)F-FDG-(OAc)_(4) with high synthesis success rate and yield,showing strong stability and practicality.

关 键 词：^(18)F-FDG-(OAc)_(4) 18F-FDG 显像剂制备 生物分布 

分 类 号：R318.6[医药卫生—生物医学工程] TH774[医药卫生—基础医学]