脑氧代谢率的功能磁共振成像方法  

Method for Functional Magnetic Resonance Imaging of Cerebral Metabolic Rate of Oxygen

作　　者：殷雅彦 李琼阁 单艺[1,2] 刘霄翊 卢洁 YIN Yayan;LI Qiongge;SHAN Yi;LIU Xiaoyi;LU Jie(Department of Radiology and Nuclear Medicine,Xuanwu Hospital,Capital Medical University,Beijing 100035,China;Beijing Key Lab of MRI and Brain Informatics,Beijing 100035,China)

机构地区：[1]首都医科大学宣武医院放射与核医学科,北京100035 [2]磁共振成像脑信息学北京市重点实验室,北京100035

出　　处：《中国医疗设备》2024年第5期137-141,168,共6页China Medical Devices

基　　金：国家自然科学青年科学基金(81901722)。

摘　　要：目的提出一种可用于脑氧代谢率(Cerebral Metabolic Rate of Oxygen,CMRO_(2))功能磁共振成像研究的方法——基于灌注的多回波非对称性自旋回波(Perfusion Multiecho Asymmetric Spin Echo,PMASE)技术。方法PMASE技术主要结合了流动敏感交替反转恢复技术与多回波非对称性自旋回波技术,可同步测量得到脑血流量(Cerebral Blood Flow,CBF)和脑氧摄取分数(Oxygen Extraction Fraction,OEF)的动态变化,根据菲克定律最终实现对CMRO_(2)动态变化的测量。研究通过右手握拳任务设计验证该技术的可行性。结果所有受试者的CBF和OEF激活区都位于左侧运动皮层,且右手握拳任务引起的CBF、OEF和CMRO_(2)的相对变化分别为-21.4%±4.5%、48.2%±9.6%和16.1%±8.3%,与先前的研究结果保持一致。结论PMASE技术具有为探索脑功能和疾病相关的CMRO2提供新的功能磁共振成像技术的潜力。Objective To propose a method that can be used for functional magnetic resonance imaging(fMRI)of cerebral metabolic rate of oxygen(CMRO_(2)),namely perfusion multiecho asymmetric spin echo(PMASE)technology.Methods The PMASE technology combined flow sensitive alternating inversion recovery and multiecho asymmetric spin echo technology.The dynamic changes of the cerebral blood flow(CBF)and oxygen extraction fraction(OEF)were measured synchronously,and the dynamic changes of CMRO_(2) was measured according to the Fick’s law.A right-hand grip task fMRI study was carried out for its verification.Results The CBF and OEF activation areas were located in the left motor cortex in all subjects,and the relative changes in CBF,OEF and CMRO_(2) induced by the right-hand grip task were-21.4%±4.5%,48.2%±9.6%and 16.1%±8.3%,respectively,consistent with previous reported values.Conclusion The PMASE technology is a potential fMRI method for exploring the changes of CMRO_(2) in brain function and brain diseases.

关 键 词：脑氧代谢率 脑血流量 脑氧摄取分数 功能磁共振成像 

分 类 号：R144.1[医药卫生—公共卫生与预防医学] R445.2