CL、phIGFBP-1、fFN及阴道微生物代谢产物在早产孕妇中的表达水平及其意义  

The Levels and Significance of CL, phIGFBP-1, fFN, and Vaginal Microbial Metabolites in Preterm Pregnant Women

作　　者：唐琳 邵秀兰 TANG Lin;SHAO Xiulan(Shanghai Jinshan District Tinglin Hospital,Shanghai 201500)

机构地区：[1]上海市金山区亭林医院,上海201500

出　　处：《医学临床研究》2024年第4期530-532,536,共4页Journal of Clinical Research

摘　　要：【目的】探讨宫颈分泌物中高磷酸化胰岛素样生长因子结合蛋白-1(phIGFBP-1)、胎儿纤维连接蛋白(fFN)、宫颈管长度(CL)以及阴道微生物代谢产物在早产孕妇中的表达水平及其意义。【方法】选取2020年9月至2021年10月在本院就诊的92例出现宫缩的未足月单胎孕妇,根据妊娠结局分为早产组(n=50)和足月组(n=42),比较两组宫颈分泌物中phIGFBP-1、fFN、CL及阴道微生物代谢产物阳性率,分析phIGFBP-1、fFN、CL的相关性及对孕妇早产的预测效能。【结果】早产组宫颈分泌物中phIGFBP-1和fFN水平显著高于足月组(P<0.05),CL显著短于足月组(P<0.05);宫颈分泌物中phIGFBP-1、fFN与CL呈负相关(r=-0.320、-0.387,P<0.05)。早产组和足月组阴道微生物代谢产物过氧化氢(H_(2)O_(2))、白细胞酯酶(LE)及唾液酸苷酶(SNA)阳性率比较,差异无统计学意义(P>0.05)。phIGFBP-1、fFN、CL及三者联合预测孕妇早产的受试者工作特征(ROC)曲线下面积分别为0.721、0.757、0.841和0.976。【结论】与足月孕妇比较,早产孕妇宫颈分泌物中phIGFBP-1、fFN水平明显升高,CL缩短,而阴道微生物代谢产物无明显差异,且phIGFBP-1、fFN和CL对孕妇早产有较好的预测效能。【Objective】To investigate the expression levels and significance of hyperphosphorylated insulin-like growth factor binding protein-1(phIGFBP-1),fetal fifinexin(fFN),cervical tube length(CL)and vaginal microbial metabolites in cervical secretions in preterm pregnant women.【Methods】A total of 92 non-full-term single pregnant women with contractions admitted to our hospital from September 2020 to October 2021 were selected and divided into preterm group(n=50)and full-term group(n=42)according to pregnancy outcomes.The positive rates of phIGFBP-1,fFN,CL and vaginal microbial metabolites in cervical secretions of the two groups were compared.The correlation among CL,fFN and phIGFBP-1 was analyzed.The predictive efficacy of phIGFBP-1,fFN,and CL in pregnant women with premature delivery was evaluated.【Results】The levels of phIGFBP-1 and fFN from cervical secretions in preterm delivery group were significantly higher than those in full-term delivery group(P<0.05),while the level of CL was significantly lower than that in full-term delivery group(P<0.05).There was a negative correlation of phIGFBP-1 and fFN with CL in cervical secretions(r=-0.320,-0.387,P<0.05).There were no significant differences in the positive rates of vaginal microbial metabolites hydrogen peroxide(H_(2)O_(2)),leucocyte esterase(LE)and sialidase(SNA)between preterm and full-term groups(P>0.05).The area under receiver operating characteristic(ROC)curve of phIGFBP-1,fFN,CL and their combination for predicting preterm birth were 0.721,0.757,0.841 and 0.976,respectively.【Conclusion】Compared to full-term pregnant women,the levels of phIGFBP-1 and fFN in preterm pregnant women were significantly higher,CL was lower,and vaginal microbial metabolites were not significantly different.The phIGFBP-1,fFN and CL have a good predictive effect on preterm delivery.

关 键 词：婴儿 早产 阴道/微生物学 孕妇 胰岛素样生长因子结合蛋白质1 纤连蛋白类 

分 类 号：R714.21[医药卫生—妇产科学]