舒芬太尼联合帕瑞昔布钠用于二次剖宫产的镇痛效果及安全性分析  

Analgesic Efficacy and Safety of Sufentanil Combined with Parecoxib Sodium for Secondary Cesarean Section

作　　者：蒋向荣[1] 呼延美 JIANG Xiangrong;HU Yanmei(Department of Anesthesiology,Hanzhong Central Hospital,Hanzhong Shaanxi 723000)

机构地区：[1]汉中市中心医院麻醉科,陕西汉中723000 [2]榆阳区妇幼保健院麻醉科,陕西榆林719000

出　　处：《医学临床研究》2024年第4期548-550,554,共4页Journal of Clinical Research

摘　　要：【目的】探讨舒芬太尼及帕瑞昔布钠用于二次剖宫产的镇痛效果及安全性。【方法】94例将行二次剖宫产的产妇,随机分为观察组与对照组,每组47例。对照组给予舒芬太尼镇痛,观察组给予舒芬太尼联合帕瑞昔布钠镇痛。比较两组围术期指标,包括手术时间、失血量、补液量、缩宫素使用类别,采用视觉模拟评分法(VAS)对两组产妇给药后3 min(T_(1))、5 min(T_(2))、10 min(T_(3))、20 min(T_(4))、30 min(T_(5))、手术结束时(T_(6))时的疼痛程度进行评估,通过多参数监护仪检测并比较两组术后1 h、6 h、24 h、48 h时血流动力学指标[血氧饱和度(SPO_(2))、心率(HR)、呼吸频率(RR)]水平,记录两组用药期间不良反应发生率。【结果】观察组与对照组手术时间、失血量、补液量、缩宫素类别比较,差异均无统计学意义(P>0.05)。T_(1)、T_(2)、T_(3)、T_(4)、T_(5)、T_(6)时,观察组VAS评分均明显低于对照组(P<0.05)。术后1 h、6 h、24 h、48 h,观察组与对照组SPO_(2)、HR、RR比较,差异均无统计学意义(P>0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】舒芬太尼联合帕瑞昔布钠用于二次剖宫产的镇痛效果优于单一使用舒芬太尼,能够维持产妇血流动力学稳定,同时具有较高安全性,临床应用价值较高。【Objective】To explore the analgesic effect and safety of Sufentanil combined with Parecoxib Sodium in secondary cesarean section.【Methods】A total of 94 parturients scheduled for secondary cesarean section were randomly divided into an observation group and a control group,with 47 cases in each.The control group received Sufentanil for analgesia,while the observation group was given a combination of Sufentanil and Parecoxib Sodium for pain relief.Perioperative parameters of both groups were compared,including operation time,blood loss,fluid replenishment,and oxytocic types.The Visual Analog Scale(VAS)was used to assess and compare the pain level of the parturients in both groups at 3 min(T_(1)),5 min(T_(2)),10 min(T_(3)),20 min(T_(4)),30 min(T_(5))post-analgesia,and at the end of surgery(T_(6)).Hemodynamic parameters[oxygen saturation(SPO_(2)),heart rate(HR),respiratory rate(RR)]were monitored and compared at 1 h,6 h,24 h,and 48 h postoperatively.Adverse reactions during the medication period were calculated.【Results】There were no significant differences in operation time,blood loss,fluid replenishment,and oxytocic types between the observation and the control groups(P>0.05).At T_(1),T_(2),T_(3),T_(4),T_(5),T_(6),the VAS scores of the observation group were significantly lower than those of the control group(P<0.05).At 1 h,6 h,24 h,and 48 h postoperatively,there were no significant differences in SPO_(2),HR,and RR levels between the observation and control groups(P>0.05).The incidence of adverse reactions was not significantly different between the two groups(P>0.05).【Conclusion】The analgesic effect of Sufentanil combined with Parecoxib Sodium in secondary cesarean section is superior to that of Sufentanil alone.It can maintain stable hemodynamics and has a high safety profile,making it clinically valuable.

关 键 词：剖宫产术 再 舒芬太尼/治疗应用 环氧化酶2抑制剂/治疗应用 镇痛 

分 类 号：R719.8[医药卫生—妇产科学]