丙泊酚诱导意识消失的脑电机制  

Electroencephalographic mechanisms of loss of consciousness induced by propofol

作　　者：陶飞 顾卫东 TAO Fei;GU Weidong(Department of Anesthesiology,Huadong Hospitai Affiliated to Fudan University,Shanghai 200040,China)

机构地区：[1]复旦大学附属华东医院麻醉科,上海市200040

出　　处：《临床麻醉学杂志》2024年第5期532-535,共4页Journal of Clinical Anesthesiology

基　　金：国家自然科学基金(82271286)。

摘　　要：脑电图可以实时连续地记录大脑区域内局部神经元自发的、有节律的电活动,评价大脑功能状态,是一种监测大脑活动的工具,广泛应用于心理学、认知功能以及意识状态等研究领域,为研究全麻药物的作用机制提供了一种新方法。丙泊酚在临床上应用广泛,分子机制已得到深入研究。丙泊酚诱导意识消失的神经脑网络机制目前尚未明确。本文回顾了常用全麻药物丙泊酚诱导意识消失的脑电特征性改变(包括功率谱、复杂度、微状态、功能连通性及脑网络拓扑特征改变)及相应的大脑功能变化,为进一步研究全麻药物的作用机制以及麻醉深度监测提供新思路。Electroencephalography can continuously record the spontaneous and rhythmic electrical activity of local neurons in the brain region in real time and evaluate the functional state of the brain,which is a tool for monitoring brain activity.It has been widely used in the research fields of psychology,cognitive function and consciousness,which provides a new approach to study the mechanism of action of general anesthetic drugs.Propofol is widely used in clinical practice,and its molecular mechanism has been deeply studied.The neural network mechanism of loss of consciousness induced by propofol is still unclear.This article reviews the changes of electroencephalogram characteristics(including power spectrum,complexity,microstate,the functional connectivity,and brain network topology characteristics change)and corres￣ponding brain functional changes of loss of conscionsness induced by propofol,the common general anesthetic,to provide a new idea for further research on the mechanism of action of anesthetic drugs and the depth of anesthesia monitoring.

关 键 词：脑电图 丙泊酚 意识消失 大脑功能 

分 类 号：R96[医药卫生—药理学]