肺炎克雷伯菌临床分布和耐药性检验分析  

Analysis of clinical distribution and drug resistance of Klebsiella pneumoniae

作　　者：张沙 ZHANG Sha(Laboratory Department,Dongda Hospital of Shan County,Heze 274300,China)

机构地区：[1]单县东大医院检验科,274300

出　　处：《中国实用医药》2024年第8期85-88,共4页China Practical Medicine

摘　　要：目的 探究肺炎克雷伯菌的临床分布和耐药性。方法 对1398株分离菌株进行研究,分析肺炎克雷伯菌的标本种类分布情况、科室分布情况、耐碳青霉烯类肺炎克雷伯菌检出情况、肺炎克雷伯菌对常规抗菌药物的耐药性。结果 在获取的1398株菌株中,肺炎克雷伯菌共298株。标本种类分布中,肺炎克雷伯菌菌株数量最多的是呼吸道标本(126株),其次为痰液标本(70株)、尿液标本(60株),发现肺炎克雷伯菌数量最少的分别为胆汁标本(1株)、腹水标本(1注)、排水标本(1株)。科室分布中,肺炎克雷伯菌菌株数量最多的是内科标本(102株),其次是外科标本(62株),再其次是其他相关科室标本(48株),数量最少的是妇产科标本(1株)。在298株肺炎克雷伯菌中,共检出耐碳青霉烯类肺炎克雷伯菌6株,占2.01%。肺炎克雷伯菌对阿米卡星、哌拉西林/他唑巴坦、厄他培南、亚胺培南、美罗培南、头孢哌酮/舒巴坦、呋喃妥因的耐药性均<10%,耐药性根据高低顺序排列依次是美罗培南<亚胺培南<厄他培南<阿米卡星<头孢哌酮/舒巴坦<哌拉西林/他唑巴坦<呋喃妥因。结论 肺炎克雷伯菌几乎是所有标本中占比最高的菌种,主要来源于呼吸道、痰液、尿液等,尤其在内科、感染科等分布最多。肺炎克雷伯菌对多种常规药物均有耐药性,在临床上应该进一步做好耐药性检测,并有针对性地选择药物,尽量降低耐药性,提升检验准确率,为临床治疗提供可靠依据。Objective To explore the clinical distribution and drug resistance test of Klebsiella pneumoniae.Methods A study of 1398 isolates was conducted to analyze the distribution of specimen species,departmental distribution,detection of carbapenem-resistant Klebsiella pneumoniae,and resistance of Klebsiella pneumoniae to conventional antimicrobial drugs.Results Among the 1398 strains obtained,there were 298 strains of Klebsiella pneumoniae.In terms of distribution of specimen species,the highest number of Klebsiella pneumoniae strains was found in respiratory specimens(126 strains),followed by sputum specimens(70 strains),urine specimens(60 strains),and the lowest number of Klebsiella pneumoniae strains were found in bile specimens(1 strain),ascites specimens(1 strain),and drainage specimens(1 strain),respectively.In terms of departmental distribution,the highest number of Klebsiella pneumoniae strains was found in internal medicine specimens(102 strains),followed by surgical specimens(62 strains),specimens from other related departments(48 strains),and the lowest number was found in obstetrics and gynecology specimens(1 strain).Among 298 strains of Klebsiella pneumoniae,6 carbapenem-resistant Klebsiella pneumoniae were detected,accounting for 2.01%.The resistance of Klebsiella pneumoniae to amikacin,piperacillin/tazobactam,ertapenem,imipenem,meropenem,cefoperazone/sulbactam,and furadantin was<10%,and the resistance ranked according to the order of high and low was meropenem<imipenem<ertapenem<amikacin<cefoperazone/sulbactam<piperacillin/tazobactam<furadantin.Conclusion Klebsiella pneumoniae is almost the highest proportion of bacteria in all samples,mainly from respiratory tract,sputum,urine,etc.,especially in the department of internal medicine,infection,etc.Klebsiella pneumoniae is resistant to a variety of conventional drugs,and drug resistance test should be further performed in clinical practice,and targeted drug selection should be carried out to reduce drug resistance as much as possible,improve the test accura

关 键 词：肺炎克雷伯菌 标本分布 耐药性 菌株 检验 

分 类 号：R446.5[医药卫生—诊断学]