亚麻籽膳食粉改善腹膜透析患者营养不良及微炎症状态的效果  

Effect of flaxseed meal on improving malnutrition and micro inflammatory status in peritoneal dialysis patients

作　　者：谢赛 李涛[1] 冯爱桥[1] XIE Sai;LI Tao;FENG Ai-qiao(Xiaogan Hospital Affiliated to Wuhan University of Science and Technology,Xiaogan 432000,China)

机构地区：[1]武汉科技大学附属孝感医院,432000

出　　处：《中国实用医药》2024年第8期167-171,共5页China Practical Medicine

基　　金：孝感市自然科学基金(项目编号:XGKJ2022010030),项目名称:医护延伸管理对持续非卧床腹膜透析病人营养不良和腹膜炎的影响。

摘　　要：目的探究亚麻籽膳食粉改善腹膜透析患者营养不良及微炎症状态的效果。方法选取进行腹膜透析治疗的60例患者,将其随机分为对照组及研究组,各30例。对照组实施常规营养治疗,研究组在对照组基础上增加亚麻籽膳食粉治疗。对比两组营养治疗前与营养治疗后1、3个月的营养状况相关指标[血清白蛋白、血清前白蛋白、体质量指数(BMI)、肱三头肌皮皱厚度、上臂肌围]水平、主观综合性营养评估(SGA)分级情况、微炎症相关指标[超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平。结果营养治疗后1个月,研究组的血清白蛋白、血清前白蛋白、BMI、肱三头肌皮皱厚度、上臂肌围分别为(50.93±5.19)g/L、(336.56±9.77)mg/L、(21.64±1.38)kg/m^(2)、(24.75±3.16)mm、(21.28±0.48)cm,对照组分别为(47.86±5.63)g/L、(330.43±10.11)mg/L、(20.82±1.57)kg/m^(2)、(22.89±3.28)mm、(20.96±0.53)cm。营养治疗后3个月,研究组的血清白蛋白、血清前白蛋白、BMI、肱三头肌皮皱厚度、上臂肌围分别为(54.22±4.88)g/L、(341.76±9.06)mg/L、(22.49±1.85)kg/m^(2)、(26.69±2.95)mm、(21.59±0.61)cm,对照组分别为(50.68±4.75)g/L、(335.51±9.85)mg/L、(21.33±1.63)kg/m^(2)、(24.45±3.22)mm、(21.15±0.59)cm。研究组营养治疗后1、3个月的血清白蛋白、血清前白蛋白、BMI、肱三头肌皮皱厚度、上臂肌围大于对照组,差异均存在统计学意义(P<0.05)。营养治疗后1、3个月,研究组SGA分级优于对照组,差异均存在统计学意义(P<0.05)。营养治疗后1个月,对照组与研究组的hs-CRP分别为(17.41±4.16)、(15.26±3.33)mg/L,IL-6分别为(42.81±8.83)、(37.46±7.92)ng/L,TNF-α分别为(131.31±20.89)、(118.55±17.61)pg/ml。营养治疗后3个月,对照组与研究组的hs-CRP分别为(13.68±3.36)、(11.58±3.15)mg/L,IL-6分别为(37.29±8.85)、(31.33±8.96)ng/L,TNF-α分别为(121.56±18.75)、(110.63±15.75)pg/ml。研究组营养治�Objective To explore the effect of flaxseed meal on improving malnutrition and micro inflammatory status in peritoneal dialysis patients.Methods A total of 60 patients undergoing peritoneal dialysis were randomly divided into a control group and a study group,with 30 patients in each group.The control group received routine nutritional treatment,and the study group received additional flaxseed meal on this basis.Both groups were compared in terms of nutritional status related indexes[serum albumin,serum prealbumin,body mass index(BMI),triceps skin-fold thickness,upper arm muscle circumference]levels,subjective global assessment(SGA)grade,microinflammation-related indexes[hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]levels before nutritional treatment and 1 and 3 months after nutritional treatment.Results 1 month after nutritional treatment,the serum albumin,serum prealbumin,BMI,triceps skin-fold thickness,and upper arm muscle circumference in the study group were(50.93±5.19)g/L,(336.56±9.77)mg/L,(21.64±1.38)kg/m^(2),(24.75±3.16)mm,and(21.28±0.48)cm;in the control group,they were(47.86±5.63)g/L,(330.43±10.11)mg/L,(20.82±1.57)kg/m^(2),(22.89±3.28)mm,and(20.96±0.53)cm.3 months after nutritional treatment,the serum albumin,serum prealbumin,BMI,triceps skin-fold thickness,and upper arm muscle circumference in the study group were(54.22±4.88)g/L,(341.76±9.06)mg/L,(22.49±1.85)kg/m^(2),(26.69±2.95)mm,and(21.59±0.61)cm;in the control group,they were(50.68±4.75)g/L,(335.51±9.85)mg/L,(21.33±1.63)kg/m^(2),(24.45±3.22)mm,and(21.15±0.59)cm.1 and 3 months after nutritional treatment,the serum albumin,serum prealbumin,BMI,triceps skin-fold thickness,and upper arm muscle circumference in the study group were greater than those in the control group,and the difference was statistically significant(P<0.05).1 and 3 months after nutritional treatment,SGA grade in the study group was better than the control group,and the difference was statistically significant(P<0.0

关 键 词：亚麻籽膳食粉 腹膜透析 营养不良 微炎症状态 

分 类 号：R692.5[医药卫生—泌尿科学]