AT1-AA、血尿酸、血尿素氮与妊娠期高血压疾病的相关性分析  

Correlation analysis of AT1-AA,serum uric acid and blood urea nitrogenwith hypertensive disorders complicating pregnancy

作　　者：王春雨 管明秀 兰淑海[3] 唐淑稳[3] 张霞[4] 曹一丹 WANG Chunyu;GUAN Mingxiu;LAN Shuhai;TANG Shuwen;ZHANG Xia;CAO Yidan(Department of Cardiovascular Medicine,Tianjin Ninghe Hospital,Tianjin 301509,China;Department of Clinical Laboratory,Baodi District People’s Hospital,Tianjin 301800,China;Department of Obstetrics,Baodi District People’s Hospital,Tianjin 301800,China;Department of Cardiovascular Medicine,Baodi District People’s Hospital,Tianjin 301800,China;Faculty of Preventive Medicine,School of Public Health,Tianjin Medical University,Tianjin 300203,China)

机构地区：[1]天津市宁河区医院心血管内科,天津301509 [2]天津市宝坻区人民医院检验科,天津301800 [3]天津市宝坻区人民医院产科,天津301800 [4]天津市宝坻区人民医院心血管内科,天津301800 [5]天津医科大学公共卫生学院预防医学系,天津300203

出　　处：《重庆医学》2024年第9期1301-1306,共6页Chongqing medicine

基　　金：天津市卫生健康委员会科技项目(ZC20083)。

摘　　要：目的分析血管紧张素Ⅱ1型受体自身抗体(AT1-AA)、血尿酸、血尿素氮与妊娠期高血压疾病(HDCP)的相关性。方法选取2021年8月至2023年2月在天津市宝坻区人民医院产科明确诊断HDCP患者125例(HDCP组),另选取同期该院收治的55例健康孕妇作为对照组。根据病情发展程度,将HDCP组分为妊娠高血压组(n=77)、子痫前期组(n=48)两个亚组。检测并比较HDCP组与对照组、妊娠高血压组与子痫前期组血尿酸、血尿素氮、AT1-AA水平等指标。结果HDCP组与对照组年龄、妊娠时间、D-二聚体、血钙、血肌酐等指标比较差异无统计学意义(P>0.05)。HDCP组外周血中AT1-AA、血尿酸及血尿素氮水平高于对照组,差异有统计学意义(P<0.05)。子痫前期组外周血中AT1-AA、血尿酸及血尿素氮水平高于妊娠高血压组,差异有统计学意义(P<0.05)。采用Spearman秩相关系数分析外周血中AT1-AA(r=0.301)、血尿酸(r=0.380)及血尿素氮(r=0.257)水平与HDCP严重程度呈正相关(P<0.01)。AT1-AA、血尿酸、血尿素氮单独检测及联合检测诊断HDCP的曲线下面积(AUC)分别为0.680、0.714、0.647、0.725,其对应的约登系数为0.368、0.380、0.306、0.439,联合检测的价值高于单独检测。结论AT1-AA、血尿酸、血尿素氮与HDCP的发生、发展存在相关性,3项联合检测的价值更高。Objective To analyze the relationship between angiotensin typeⅡ1 receptor autoantibodies(AT1-AA),blood uric acid and urea nitrogen with hypertensive disorder complicating pregnancy(HDCP).Methods A total of 125 patients with HDCP diagnosed in the obstetrics department of Tianjin Municipal Baodi District People’s Hospital from August 2021 to February 2023 were randomly selected as the HDCP group,and 55 healthy pregnant women admitted to this hospital during the same period were selected as the control group.The HDCP group was divided into the gestational hypertension subgroup(n=77)and preeclampsia group(n=48)according to the degree of disease progression.The levels of serum uric acid,blood urea nitrogen and AT1-AA were detected and compared between the HDCP group and control group and between the gestational hypertension subgroup and preeclampsia subgroup.Results There were no statistically significant differences in the age,gestational time,D-dimer,serum calcium and serum creatinine between the control group and the HDCP group(P>0.05).The levels of peripheral blood AT1-AA,serum uric acid and blood urea nitrogen in the HDCP group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of peripheral blood AT1-AA,serum uric acid and blood urea nitrogen in the preeclampsia subgroup were significantly higher than those in the gestational hypertension subgroup,and the differences were statistically significant(P<0.05).The Spearman rank correlation coefficient analysis showed that the levels of peripheral blood AT1-AA(r=0.301),serum uric acid(r=0.380)and blood urea nitrogen(r=0.257)levels were positively correlated with the severity degree of HDCP(P<0.01).The area under the curve(AUC)of AT1-AA,serum uric acid and blood urea nitrogen detection alone and combined detection in the diagnosis of HDCP were 0.680,0.714,0.647 and 0.725,and the corresponding Youden coefficients were 0.368,0.380,0.306 and 0.439,indicating that the value of combined testing was higher th

关 键 词：妊娠期高血压疾病 血管紧张素Ⅱ1型受体自身抗体 血尿酸 血尿素氮 相关性 

分 类 号：R714.246[医药卫生—妇产科学]