基于氧化应激及肾纤维化指标分析益气滋阴化瘀通络方治疗气阴两虚型IgA肾病的有效性  

Based on oxidative stress and renal fibrosis indicators to analyze the effectiveness of Yiqi Ziyin Huayu Tongluo decoction in the treatment of IgA nephropathy with deficiency of both qi and yin

作　　者：路博宇[1] 唐晨思 张孝利 向广生 LU Boyu;TANG Chensi;ZHANG Xiaoli(Nephrology Department of Shijiazhuang Traditional Chinese Medicine Hospital(East Hospital District),Shijiazhuang Hebei 050000,China;North China Medical and Health Group Shijiazhuang Huayao Hospital Nephrology Department,Shijiazhuang Hebei 050000,China)

机构地区：[1]石家庄市中医院(东院区)肾病科,河北石家庄050000 [2]华北医疗健康集团石家庄华药医院肾病科,河北石家庄050000

出　　处：《四川中医》2024年第3期133-136,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(编号:2019407)。

摘　　要：目的:分析益气滋阴化瘀通络方治疗气阴两虚型IgA肾病对患者氧化应激指标、肾纤维化指标的影响。方法:收集气阴两虚型IgA肾病患者84例,随机分组为对照组(42例,基础治疗)及研究组(42例,基础治疗+益气滋阴化瘀通络方),进行疗效评定,采集患者肘静脉血测量血清氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)]、肾纤维化指标[透明质酸酶(HA)、层粘连蛋白(LN)]、肾功能指标[尿素氮(BUN)、血肌酐(Scr)],记录患者治疗过程中头晕头痛、恶心呕吐、嗜睡等不良反应。结果:治疗总有效率比较,研究组显著高于对照组(P<0.05);治疗后研究组血清SOD水平高于对照组,MDA水平低于对照组(P<0.05);治疗后研究组血清HA及LN显著低于对照组(P<0.05);治疗后研究组BUN及Scr水平显著低于对照组(P<0.05);组间恶心呕吐、嗜睡等不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:利用益气滋阴化瘀通络方治疗IgA肾病可减轻患者氧化应激反应,延缓肾纤维化进程,肾功能改善效果明显,整体疗效突出,安全性高。Objective:To analyze the effect of Yiqi Ziyin Huayu Tongluo Decoction in treating IgA nephropathy with deficiency of both Qi and Yin on oxidative stress indexes and renal fibrosis indexes.Methods:84patients with IgA nephropathy of Qi and Yin deficiency type were collected and randomly divided into a control group(42cases,basic treatment)and a research group(42cases,basic treatment+Yiqi Ziyin Huayu Tongluo prescription),and the efficacy was evaluated.The patient's cubital venous blood was measured for serum oxidative stress indicators.[malondialdehyde(MDA),superoxide dismutase(SOD)],renal fibrosis indicators[hyaluronidase(HA),laminin(LN)],renal function indicators[blood urea nitrogen(BUN),serum creatinine(Scr)],Adverse reactions such as dizziness,headache,nausea and vomiting,and lethargy were recorded during the treatment.Results:Compared with the total effective rate of treatment,the research group was significantly higher than the control group(P<0.05);after treatment,the serum SOD level of the research group was higher than that of the control group,and the MDA level was lower than that of the control group(P<0.05);HA and LN were significantly lower than those in the control group(P<0.05);after treatment,the levels of BUN and Scr in the study group were significantly lower than those in the control group(P<0.05);there was no significant difference in the total incidence of adverse reactions such as nausea,vomiting,and lethargy among the groups Scientific significance(P>0.05).Conclusion:Using Yiqi Ziyin Huayu Tongluo Decoction to treat IgA nephropathy can reduce the oxidative stress response of patients,delay the process of renal fibrosis,improve renal function significantly,and have outstanding overall curative effect and high safety.

关 键 词：IGA肾病 益气滋阴化瘀通络方 随机对照 氧化应激 肾纤维化 

分 类 号：R692.3[医药卫生—泌尿科学]