慢性失眠患者睡眠反应性和抑郁焦虑水平与主客观睡眠质量间相关性研究  

Study on Correlation of Sleep Reactivity,Depression and Anxiety Level with Sleep Quality in Patients with Chronic Insomnia

作　　者：厉雪艳 杨叶 张月明 胡孝朋[3] 闫芳芳 葛义俊[1] LI Xueyan;YANG Ye;ZHANG Yueming;HU Xiaopeng;YAN Fangfang;GE Yijun(Department of Sleep Disorders,Chaohu Hospital Affiliated to Anhui Medical University,Chaohu 238000,China;Department of Neurology,The Second People’s Hospital of Hefei,Hefei 230000,China;Department of Radiology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China;Department of Psychology,University of Chinese Academy of Sciences,Beijing 101408,China)

机构地区：[1]安徽医科大学附属巢湖医院睡眠障碍科,巢湖238000 [2]合肥市第二人民医院神经内科,合肥230000 [3]安徽医科大学第一附属医院放射科,合肥230022 [4]中国科学院心理研究所,北京100101 [5]中国科学院大学心理学系,北京101408

出　　处：《载人航天》2024年第2期191-196,共6页Manned Spaceflight

基　　金：载人航天工程航天医学实验领域项目(HYZHXM03004);安徽省转化医学研究院科研基金(2022zhyx-C57);2022年度安徽省卫生健康科研基金一般项目(AHWJ2022b027)。

摘　　要：为探讨慢性失眠(CI)患者睡眠反应性、睡前觉醒、压力和抑郁焦虑水平改变及和主客观睡眠质量间的关系,招募88名志愿者,分为CI组(61例)和对照组(27例),采用匹兹堡睡眠质量指数(PSQI)、多导睡眠图(PSG)评估睡眠质量;采用福特应激睡眠反应量表(FIRST)、睡前觉醒状态量表(PSAS)、压力知觉量表(CPSS)和汉密尔顿抑郁(HAMD)、焦虑量表(HAMA)分别评估睡眠反应性、压力、觉醒和抑郁焦虑水平。结果表明:与对照组比较,CI组HAMD、HAMA、PSAS、FIRST和CPSS分显著增加(P<0.001),CI患者睡眠反应性和觉醒次数、N2期占比呈正相关,睡前觉醒、压力水平与睡眠潜伏期、觉醒次数呈正相关,焦虑分和睡眠潜伏期正相关,焦虑分和抑郁分都与睡眠效率呈负相关(P<0.05),ROC分析提示它们可能是区分CI患者和健康者较好的预测指标。CI组患者睡眠反应性、抑郁焦虑水平增高,且和CI组患者觉醒增加、睡眠效率降低关联。To investigate the relationship between sleep reactivity,sleep awakening,stress,depression and anxiety levels and subjective and objective sleep quality in patients with chronic insomnia(CI),88 volunteers were recruited and divided into CI group(61 cases)and control group(27 cases).Pittsburgh Sleep Quality Index(PSQI)and polysomnography(PSG)were used to evaluate the sleep quality.The levels of sleep reactivity,stress,arousal,depression and anxiety were evaluated by Ford Stress Sleep Response Scale(FIRST),PSAS,Stress perception Scale and Hamilton Depression and Anxiety Scale(HAMD and HAMA),respectively.The results showed that compared with the control group,the scores of HAMD,HAMA,PSAS,FIRST and CPSS in CI group increased(P<0.001);sleep reactivity was positively correlated with the number of awakenings and N2 stage in CI patients;awakening before bedtime and stress level were positively correlated with sleep latency and wake up times.Anxiety scores were positively correlated with sleep latency,and anxiety scores and depression scores were negatively correlated with sleep efficiency(P<0.05).ROC analysis suggested that they may be good predictors to distinguish CI patients from healthy people.Sleep reactivity,depression and anxiety were increased in CI patients,and were associated with increased arousal and decreased sleep efficiency in CI patients.

关 键 词：慢性失眠 睡眠反应性 抑郁/焦虑 睡眠质量 

分 类 号：V7[航空宇航科学技术]