脑小血管病认知功能障碍的中医药防治研究进展  

Research Progress in TCM Prevention and Treatment of Vascular Cognitive Impairment Caused by Cerebral Small Vessel Disease

作　　者：陈雪妍 黄梦妮 秦秀德[1,2] 江丰[3] 莫嘉欣 CHEN Xueyan;HUANG Mengni;QIN Xiude;JIANG Feng;MO Jiaxin(The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou 510006,China;Shenzhen Traditional Chinese Medicine Hospital,Shenzhen 518033,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;The First Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou 510499,China)

机构地区：[1]广州中医药大学第四临床医学院,广州510006 [2]深圳市中医院,深圳518033 [3]天津中医药大学,天津301617 [4]广州中医药大学第一临床医学院,广州510499

出　　处：《世界中医药》2024年第5期747-752,共6页World Chinese Medicine

基　　金：国家自然科学基金项目(81804004)——脑髓康通过调控CypA/NF-κB/MMP9通路保护血脑屏障及Aβ转运机制改善痴呆动物模型认知功能的机制研究;国家自然科学基金项目(81904103)——从NS1拮抗IFN-β作用途径探讨基于“风热毒”邪论治的热毒宁注射液抗甲型H1N1流感病毒机制;深圳市“医疗卫生三名工程”项目(SZZYSM 202111011)——天津中医药大学张伯礼院士中医临床团队。

摘　　要：脑小血管病认知功能障碍(CSVD-VCI)是在脑小血管病基础上,引起认知功能受损的一类临床综合征。近年来,随着人口老龄化的加速,CSVD-VCI的发病率逐年上升,早诊断早治疗对该病的防治具有重要意义。CSVD-VCI属于中医学健忘、痴呆的范畴,中医学认为其病机涉及虚、痰、瘀、毒等多种因素,可分为脏腑亏虚型、痰瘀阻络型、毒损脑络型等主要证候类型。中医通过辨证论治在该病的治疗中发挥着重要作用,并取得显著进展,本文就CSVD-VCI的病因病机、辨证分型以及近年来中药单药、复方治疗该病的动物实验和临床研究展开综述,为中医药治疗CSVD-VCI提供参考依据。Vascular cognitive impairment caused by cerebral small vessel disease(CSVD-VCI)is a clinical syndrome of cognitive impairment on the basis of cerebral small vessel disease.As population aging is accelerating in recent years,the incidence of CSVD-VCI is increasing year by year.Early diagnosis and treatment are of great significance to the prevention and treatment of CSVD-VCI.According to the TCM theory,CSVD-VCI is a disease of amnesia and dementia caused by multiple factors including deficiency,phlegm,stasis,and toxin.The patients mainly present the syndromes of deficiency in zang-fu organs,phlegm-stasis obstructing collaterals,or toxin damaging brain collateral.TCM plays an important role in the diagnosis and treatment of CSVD-VCI based on syndrome differentiation.Therefore,this paper reviews the research progress in the etiology,pathogenesis,syndrome differentiation of CSVD-VCI as well as the animal experiments and clinical trials about the treatment of this disease with single Chinese medicines and TCM compound prescriptions,aiming to provide a reference for the TCM treatment of CSVD-VCI.

关 键 词：脑小血管病 认知功能障碍 病因 病机 证型 治疗 研究进展 

分 类 号：R2[医药卫生—中医学]