加味当归芍药散联合针刺治疗肾虚血瘀证月经过少临床研究  

Clinical Study on Modified Danggui Shaoyao San Decoction Combined with Acupuncture for Hypomenorrhea with Syndrome of Kidney Deficiency with Blood Stasis

作　　者：李芳 赵亮 王静 库玉花 范道艳 LI Fang;ZHAO Liang;WANG Jing;KU Yuhua;FAN Daoyan(Department of Gynecology,Chinese Medicine Hospital of Puyang,Puyang Henan 457000,China;Institute ofOncology,Zhanjiang First Hospital of Traditional Chinese Medicine,Zhanjiang Guangdong 524000,China)

机构地区：[1]濮阳市中医医院妇科,河南濮阳457000 [2]湛江市第一中医医院肿瘤研究所,广东湛江524000

出　　处：《新中医》2024年第7期30-35,共6页New Chinese Medicine

摘　　要：目的:观察加味当归芍药散联合针刺治疗肾虚血瘀证月经过少的疗效。方法:选取180例肾虚血瘀证月经过少患者,按随机数字表法分为对照组、加味当归芍药散组、针刺组、联合组各45例。对照组采用常规现代医学治疗,加味当归芍药散组采用常规现代医学联合加味当归芍药散治疗,针刺组实施常规现代医学联合针刺治疗,联合组采用常规现代医学联合加味当归芍药散和针刺治疗。4组均治疗3个月经周期。观察4组治疗前后中医症状评分、月经量和子宫内膜厚度、性激素水平的变化,比较2组临床疗效及不良反应发生情况。结果:治疗后,4组中医症状评主症评分、次症评分及总分均较治疗前下降(P<0.05),加味当归芍药散组、针刺组、联合组上述3项评分均低于对照组(P<0.05),联合组上述3项评分均低于对照组、加味当归芍药散组、针刺组(P<0.05)。治疗后,4组月经量、子宫内膜厚度均较治疗前增加(P<0.05),加味当归芍药散组、针刺组、联合组月经量及子宫内膜厚度均高于对照组(P<0.05),联合组月经量、子宫内膜厚度均高于对照组、加味当归芍药散组、针刺组(P<0.05)。治疗后,加味当归芍药散组、针刺组、联合组总有效率均优于对照组(P<0.05),联合组临床疗效优于加味当归芍药散组、针刺组、对照组(P<0.05)。治疗后,4组血清雌二醇(E_(2))水平均较治疗前升高(P<0.05),血清卵泡刺激素(FSH)、黄体生成素(LH)水平均较治疗前下降(P<0.05);加味当归芍药散组、针刺组、联合组血清E_(2)水平均高于对照组(P<0.05),加味当归芍药散组、针刺组、联合组血清FSH、LH水平均低于对照组(P<0.05);联合组血清E_(2)水平高于其他3组(P<0.05),血清FSH、LH水平低于其他3组(P<0.05)。对照组、加味当归芍药散组、针刺组、联合组的不良反应发生率分别为4.76%、6.98%、7.14%、14.29%,4组比较,差异无统计学意义(P>0.05)。结Objective:To observe the curative effect of modified Danggui Shaoyao San Decoction combined with acupuncture on hypomenorrhea with syndrome of kidney deficiency with blood stasis.Methods:A total of 180 patients with hypomenorrhea with syndrome of kidney deficiency with blood stasis were selected and divided into the control group,the modified Danggui Shaoyao San Decoction group,the acupuncture group and the combination group,with 45 cases in each group.The control group was given routine modern medicine for treatment;the modified Danggui Shaoyao San Decoction group was treated with routine modern medicine combined with modified Danggui Shaoyao San Decoction;the acupuncture group was treated with routine modern medicine combined with acupuncture,and the combination group was treated with routine modern medicine combined with modified Danggui Shaoyao San Decoction.The four groups were treated for three menstrual cycles.The traditional Chinese medicine(TCM)symptom scores,menstrual volume,endometrial thickness,curative effects,levels of sex hormones and incidence of adverse reactions before and after treatment were considered the observation indexes.Results:After treatment,the TCM symptom scores,scores of primary and secondary symptoms and the total scores in the four groups were decreased when compared with those before treatment(P<0.05),and the above three scores in the modified Danggui Shaoyao Powder group,the acupuncture group and the combination group were lower than those in the control group(P<0.05),and the above three scores in the combination group were lower than those in the control group,the modified Danggui Shaoyao Powder group and the acupuncture group(P<0.05).After treatment,the menstrual volume and endometrial thickness in the four groups were increased when compared with those before treatment(P<0.05),and the above two indexes in the modified Danggui Shaoyao San Decoction group,the acupuncture group and the combination group were higher than those in the control group(P<0.05),and the above two indexe

关 键 词：月经过少 肾虚血瘀证 加味当归芍药散 针刺 子宫内膜厚度 性激素 

分 类 号：R271.111[医药卫生—中医妇科学]