养心方联合美托洛尔对心虚胆怯型心悸患者中医证候积分及血液流变学的影响  

Effects of Yangxin formula combined with metoprolol on traditional Chinese medicine syndrome scores and hemorheology in patients with palpitations of fright due to deficiency of heart-energy type

作　　者：刘怡静 董耀荣[2] Liu Yijing;Dong Yaorong(Department of Traditional Chinese Medicine,Daning Road Community Health Service Center,Jing′an District,Shanghai 200070,China;不详)

机构地区：[1]上海市静安区大宁路街道社区卫生服务中心中医科,200070 [2]上海市中医医院心病科

出　　处：《山西医药杂志》2024年第6期432-436,共5页Shanxi Medical Journal

摘　　要：目的探究养心方联合美托洛尔对心虚胆怯型心悸患者中医证候积分及血液流变学的影响。方法通过随机数字表法将选取的120例于2020年1月至2023年1月来本院进行心虚胆怯型心悸治疗的患者分为观察组(60例)和对照组(60例),对照组患者采用琥珀酸美托洛尔进行治疗,观察组在对照组治疗的基础上给予养心方,对2组患者的临床疗效、中医证候积分水平、血液流变学指标和不良反应作对比。结果临床总有效率在观察组为97%(58/60),在对照组中为83%(50/60),比较差异有统计学意义(P<0.05);2组患者治疗后的心悸、气短、易惊、烦躁、少寐、乏力等中医证候积分水平均有下降,但对照组不及观察组下降幅度显著(P<0.05);2组患者治疗后的全血高切黏度(HBV)、全血低切黏度(LBV)和纤维蛋白原(FIB)等血液流变学指标均有下降,且对照组下降幅度小于观察组(P<0.05);观察组的不良反应发生率为3%(2/60),对照组为18%(11/60),经比较差异有统计学意义(P<0.05)。结论养心方联合美托洛尔能够有效降低心虚胆怯型心悸患者的中医证候积分水平,改善机体血流情况。Objective To explore the effects of the Yangxin formula combined with metoprolol on Traditional Chinese Medicine(TCM)syndrome scores and hemorheology in patients with palpitations of fright due to deficiency of heart energy type.Methods From January 2020 to January 2023,120 patients who came to our hospital for the treatment of palpitations of fright due to deficiency of heart-energy type were separated into an observation group(60 cases)and a reference group(60 cases)using a random number table.The reference group was treated with metoprolol succinate,while the observation group was given Yangxin formula based on the reference group's treatment.The clinical efficacy,TCM syndrome score level,hemorheological indicators,and untoward reactions in the two groups were compared.Results The total clinical effective rate was 97%(58/60)in the observation group and 83%(50/60)in the reference group,with a statistically obvious difference(P<0.05).After treatment,the scores of TCM syndromes such as palpitations,shortness of breath,irritability,insomnia,and fatigue in both groups decreased,but the decrease in the reference group was not obvious compared to the observation group(P<0.05).After treatment,the hemorheological indicators such as whole blood high shear viscosity(HBV),whole blood low shear viscosity(LBV),and fibrinogen(FIB)decreased in both groups,and the decrease in the reference group was smaller than that in the observation group(P<0.05).The incidence of untoward reactions in the observation group was 3%(2/60),while that in the reference group was 18%(11/60),and the difference was statistically obvious(P<0.05).Conclusion The combination of Yangxin formula and metoprolol can effectively reduce the TCM syndrome score level of patients with palpitations of fright due to a deficiency of heart-energy type,and improve the body′s blood flow situation.

关 键 词：心悸 养心方 美托洛尔 证候 血液流变学 

分 类 号：R541.7[医药卫生—心血管疾病]