糖代谢异常对血清激活素A水平的影响  

Effect of glucose metabolic disorders on serum levels of activin-A

作　　者：刘童君 赵雅洁[1] 胡洁玲 胡洋 梁伟[1] LIU Tongjun;ZHAO Yajie;HU Jieling;HU Yang;LIANG Wei(Department of Geriatrics,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Department of Radiology,Qilu Hospital(Qingdao),Shandong University,Qingdao 266034,China)

机构地区：[1]上海交通大学医学院附属瑞金医院老年科,上海市200025 [2]山东大学齐鲁医院(青岛)放射科,山东省青岛市266034

出　　处：《实用老年医学》2024年第5期495-499,共5页Practical Geriatrics

基　　金：上海市卫生健康委员会卫生行业临床研究专项项目(202140052)。

摘　　要：目的 探讨老年人群血清激活素A(ACT-A)的表达情况及其在不同血糖状态病人中的影响因素。方法 纳入2022年7月至2023年2月期间瑞金医院特需病房体检人群293例,检测其血清ACT-A水平,分析不同临床特征病人ACT-A的表达差异及不同血糖状态病人中ACT-A的影响因素。结果 ACT-A水平随着年龄的增长和糖尿病病情进展均升高(P<0.01)。HbA1c≥7%、合并有中度肾功能不全、高血压病史、脉压>55 mmHg及脉压指数>0.45的老年糖尿病病人ACT-A水平更高。糖尿病人群中,Pearson相关分析及线性回归均证实ACT-A水平与年龄、HbA1c及胰岛素抵抗指数(HOMA-IR)呈正相关(P均<0.05),与空腹胰岛素水平呈负相关(P<0.05)。结论 衰老个体体内ACT-A水平增加,且与年龄呈正相关;ACT-A水平在糖尿病前期即可升高,在糖尿病阶段进一步升高;年龄、HbA1c、空腹胰岛素及HOMA-IR与糖尿病病人ACT-A水平独立相关。Objective To explore the expression of serum ACT-A in the elderly with different glucose staus.Methods A total of 293 stable patients who underwent physical examination in the VIP department of Ruijin Hospital from July 2022 to February 2023 were enrolled.The serum ACT-A level was detected,and the expression differences of ACT-A in the patients with different clinical characteristics and the influencing factors in the patients with different glucose status were analyzed.Results The level of ACT-A increased with age and the progression of diabetes(P<0.01).The level of ACT-A was higher in elderly diabetic patients with HbA1c≥7%,renal insufficiency,hypertension history,pulse pressure>55 mmHg and pulse pressure index>0.45.In diabetes population,Pearson correlation analysis and linear regression confirmed that the level of ACT-A was positively correlated with age,HbA1c,and HOMA-IR(B=20.996,33.391,57.482,P<0.05),and negatively correlated with the level of fasting insulin(B=-17.794,P<0.05).Conclusions The level of ACT-A is positively correlated with age.The level of ACT-A can be increased in the patients with prediabetes,and further increased in the patients with diabetes.Age,HbA1c,HOMA-IR and fasting insulin are independently associated with ACT-A level in diabetic patients.

关 键 词：激活素A 衰老 糖尿病 糖尿病前期 

分 类 号：R587.1[医药卫生—内分泌]