肝-胰岛α细胞轴在糖尿病和脂肪肝中的作用研究进展  

Research progress on the role of the liver-α cell axis in diabetes mellitus and fatty liver disease

作　　者：张世璇 张俊清[1] 郑佳 Zhang Shixuan;Zhang Junqing;Zheng Jia(Department of Endocrinology,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院内分泌科,北京100034

出　　处：《国际内分泌代谢杂志》2024年第2期132-135,140,共5页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金项目(81800703);北京市科技新星(Z201100006820117);北京市科技新星交叉合作课题(20220484181)。

摘　　要：肝-胰岛α细胞轴是一种生理性反馈环路, 主要涉及两个主要环节, 包括胰高血糖素促进氨基酸代谢, 以及氨基酸调节胰岛α细胞增生和胰高血糖素分泌。肝-胰岛α细胞轴可以同时调控葡萄糖、脂质及氨基酸的代谢, 与2型糖尿病及非酒精性脂肪性肝病密切相关。明晰肝-胰岛α细胞轴的调控作用有望为治疗2型糖尿病及非酒精性脂肪性肝病提供潜在的治疗靶点。The liver-αcell axis is a physiological feedback loop involving two main components:glucagon promoting amino acid metabolism and amino acids regulating the proliferation of pancreatic alpha cells and the secretion of glucagon.The liver-αcell axis can simultaneously regulate the metabolism of glucose,lipids,and amino acids,and is closely associated with type 2 diabetes mellitus and nonalcoholic fatty liver disease.Clarifying the regulatory role of the liver-αcell axis holds potential as a therapeutic target for the treatment of type 2 diabetes mellitus and nonalcoholic fatty liver disease.

关 键 词：肝-胰岛α细胞轴 胰高血糖素 2型糖尿病 非酒精性脂肪性肝病 

分 类 号：R587.1[医药卫生—内分泌] R575.5[医药卫生—内科学]