基于复杂网络的慢性胃炎脾胃湿热证症状/体征群特征研究  

Study on Symptom/Signs Group of Spleen and Stomach Damp-heat Syndrome of Chronic Gastritis by complex network

作　　者：郭本琼 刘怡[1] 徐玮斐 刘国萍[1] GUO Ben-qiong;LIU Yi;XU Wei-fei;LIU Guo-ping(School of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学中医学院,上海201203

出　　处：《时珍国医国药》2024年第2期499-503,共5页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(81873236,81270050);上海市卫生健康委员会科技项目(202340166);上海市健康辨识与评估重点实验室科技项目(21DZ2271000)。

摘　　要：目的以复杂网络理论为基础,探索慢性胃炎脾胃湿热证复杂网络中关联紧密的症状/体征群特征,以期为慢性胃炎中医证候客观化研究提供新的思路和方法。方法综合应用度值、介数中心性、接近中心性以及“k-core层次分析法”分析方法,寻找慢性胃炎脾胃湿热证复杂网络中关联紧密的症状/体征群,并深入挖掘其社团内部结构特点。结果寻找到关联程度最高的4个症状/体征群,社团0包括舌苔偏于舌根、苔遍布全舌、舌瘦薄、面色萎黄;社团1包括嘈杂、舌色红、唇色红、右手脉弦、面色红;社团2包括手足心热、苔薄、口酸;社团3包括胖大舌、口气重、苔黄白相兼,病位要素涉及脾、胃、肝、肾。结论综合运用复杂网络数据分析方法寻找到的4个关联程度最高的症状/体征群特征与中医理论基本相符,部分结果与中医理论有出入,可能与临床证候具有兼挟性、动态性、复杂性有关。Objective Based on the complex network theory,this paper explores the closely related symptom/sign group characteristics in the complex network of spleen-stomach damp-heat syndrome in chronic gastritis,in order to provide new ideas and methods for the objective study of chronic gastritis syndrome in traditional Chinese medicine.Methods The degree,between centrality,closeness centrality and"k-core analytic hierarchy process"were integrated to find the closely related symptom/sign group in the complex network of spleen and stomach damp-heat syndrome of chronic gastritis,and the internal structure of the community was deeply explored.Results The 4 symptom/sign groups with the highest correlation were found.Community 0 included tongue coating on the root of the tongue,covering the whole tongue,thin tongue and yellow complexion;Community 1 includes noise,red tongue,red lips,right hand pulse string,red face;Community 2 includes hot hands and feet,thin fur,and sour mouth;Community 3 includes fat tongue,heavy breath,yellow and white fur,and the factors of disease location involve spleen,stomach,liver and kidney.Conclusion The characteristics of the four most correlated symptom/sign groups found by comprehensive use of complex network data analysis method are basically consistent with the theory of traditional Chinese medicine,and some results are different from the theory of traditional Chinese medicine,which may be related to the concurrent,dynamic and complex clinical syndroms.

关 键 词：慢性胃炎 脾胃湿热证 复杂网络 症状/体征群特征 关联分析 

分 类 号：R256.3[医药卫生—中医内科学]