The LRR receptor-like kinase ALR1 is a plant aluminum ion sensor  

作　　者：Zhong Jie Ding Chen Xu Jing Ying Yan Yu Xuan Wang Meng Qi Cui Jun Jie Yuan Ya Nan Wang Gui Xin Li Jian Xiang Wu Yun Rong Wu Ji Ming Xu Chun Xiao Li Yuan Zhi Shi Chuan Zao Mao Jiang Tao Guo Jian Min Zhou Moussa Benhamed Nicholas P.Harberd Shao Jian Zheng 

机构地区：[1]State Key Laboratory of Plant Environmental Resilience,College of Life Sciences,Zhejiang University,Hangzhou,Zhejiang,China [2]Guangdong Laboratory for Lingnan Modern Agriculture,College of Natural Resources and Environment,South China Agricultural University,Guangzhou,Guangdong,China [3]Agricultural Experimental Station,Zhejiang University,Hangzhou,Zhejiang,China [4]State Key Laboratory of Rice Biology,Institute of Biotechnology,Zhejiang University,Hangzhou,Zhejiang,China [5]Tea Research Institute,Chinese Academy of Agricultural Sciences,Hangzhou,Zhejiang,China [6]Medical School,Zhejiang University,Hangzhou,Zhejiang,China [7]Center for Genome Biology and State Key Laboratory of Plant Genomics,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing,China [8]UniversitéParis-Saclay,CNRS,INRAE,Univ Evry,Institute of Plant Sciences Paris-Saclay(IPS2),Orsay,France [9]Department of Biology,University of Oxford,Oxford,UK [10]Institute of Ecological Civilization,Zhejiang University,Hangzhou,Zhejiang,China

出　　处：《Cell Research》2024年第4期281-294,共14页细胞研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(31730006);the Ministry of Science and Technology of China(2015CB942903);the National Key R&D Program of China(2022YFA1303402);the National Natural Science Foundation of China(31970272);Guangdong Laboratory for Lingnang Modern Agriculture(NT2021010);the“111”project from the Ministry of Education Bureau of Foreign Experts of China(B14027)。

摘　　要：Plant survival requires an ability to adapt to differing concentrations of nutrient and toxic soil ions,yet ion sensors and associated signaling pathways are mostly unknown.Aluminum(Al)ions are highly phytotoxic,and cause severe crop yield loss and forest decline on acidic soils which represent∼30%of land areas worldwide.Here we found an Arabidopsis mutant hypersensitive to Al.The gene encoding a leucine-rich-repeat receptor-like kinase,was named Al Resistance1(ALR1).Al ions binding to ALR1 cytoplasmic domain recruits BAK1 co-receptor kinase and promotes ALR1-dependent phosphorylation of the NADPH oxidase RbohD,thereby enhancing reactive oxygen species(ROS)generation.ROS in turn oxidatively modify the RAE1 F-box protein to inhibit RAE1-dependent proteolysis of the central regulator STOP1,thus activating organic acid anion secretion to detoxify Al.These findings establish ALR1 as an Al ion receptor that confers resistance through an integrated Al-triggered signaling pathway,providing novel insights into ion-sensing mechanisms in living organisms,and enabling future molecular breeding of acid-soiltolerant crops and trees,with huge potential for enhancing both global food security and forest restoration.

关 键 词：FOREST CROPS thereby 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]