Oligopeptide Self-Assembly:Mechanisms,Stimuli-Responsiveness,and Biomedical Applications  

作　　者：Lei Ge Hanyan Xu Xin Jiang Jing Yu 

机构地区：[1]School of Materials Science and Engineering,Nanyang Technological University,Singapore 637553 [2]Institute for Digital Molecular Analytics and Science,Nanyang Technological University,Singapore 637553

出　　处：《CCS Chemistry》2024年第1期69-90,共22页中国化学会会刊（英文）

基　　金：the Singapore National Research Fel-lowship(NRF-NRFF11-2019-0004);the Singapore Ministry of Education(MOE)Tier 2 Grant(MOE-T2EP30220-0006)for their support.

摘　　要：Oligopeptide self-assembly materials have emerged as a promising class of biomaterials with diverse applications in biomedicine.This review highlights the recent progress in comprehending the selfassembly mechanisms intrinsic to oligopeptides and their behavior in response to specific stimuli.By methodically structuring the amino acid sequence and managing external stimuli such as pH levels,redox conditions,or enzymatic activity,we can exercise unprecedented control over the self-assembly process.By controlling the self-assembly process of oligopeptides,various structures with extraordinary versatility can be obtained,including micelles,nanofibers,and coacervate droplets,each possessing modifiable mechanical and chemical properties.Furthermore,these self-assembled constructs demonstrate immense potential within varied biomedical applications.The stimuli-sensitive nature of oligopeptide assembly materials facilitates timely encapsulation and release of therapeutic cargos,consequently eliciting desired cellular responses.This approach paves the way for more precise tumor targeting,personalized medicinal treatments,and well-regulated drug dispensation.Their innate biocompatibility and proficiency in replicating the extracellular matrix(ECM)render them ideally suited for applications such as tissue engineering,wound remediation,and regenerative medicine.In summary,oligopeptide self-assembling materials show tremendous potential as adaptable platforms for cutting-edge biomedical applications,thereby bridging the divide between fundamental research and practical clinical application.

关 键 词：OLIGOPEPTIDES SELF-ASSEMBLY NONEQUILIBRIUM stimuli-responsive behavior biomedical applications 

分 类 号：O62[理学—有机化学]