Direct Synthesis of α-Aminophosphonates from Amines,Alcohols,and White Phosphorus  

作　　者：Mengpei Bai Yinwei Cao Junwei Huang Yan Liu Guo Tang Yufen Zhao 

机构地区：[1]Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen,Fujian 361005

出　　处：《CCS Chemistry》2024年第1期91-99,共9页中国化学会会刊（英文）

基　　金：the National Key Research and Development Program of China(grant no.2020YFA0608300);the Space Application System of China Manned Space Program(grant no.KJZ-YY-WSM01);National Natural Science Foundation of China(grant nos.21772163,21778042,and 41876072).

摘　　要：Developing practical strategies for the synthesis of organophosphorus compounds(OPCs)from white phosphorus(P_(4))without the use of Cl_(2) and PCl_(3) remains a significant challenge.The first multicomponent oxidative α-phosphonylation of amines with P_(4) and alcohols has been developed.With the use of copper(Ⅱ)as the catalyst and air as the safe oxidant,structurally sophisticated α-aminophosphonates have been prepared in high yields.Furthermore,this method is also suitable for selective construction of P-O-P compounds.The reaction is characterized by a complete conversion of P_(4).The activation of P_(4) with transition metals often leads to formation of complexes[M_(x)P_(y)]_(n) associated with the deactivation of transition metals.This breakthrough showcases the potential of transition-metal-catalyzed reactions in elemental phosphorus chemistry.

关 键 词：white phosphorus P-C bonds dialkyl phosphites AMINOPHOSPHONATES PYROPHOSPHATES 

分 类 号：O62[理学—有机化学]