Body-Shaping Membrane to Regenerate Breast Fat by Elastic Structural Holding  

作　　者：Hye-Seon Kim Jeongeun Park Hyun-Su Ha Sewoom Baek Chan Hee Lee Kyubae Lee Suji Park Jueun Kim Se Won Yi Hak-Joon Sung 

机构地区：[1]Department of Medical Engineering,Graduate School of Medical Science,Brain Korea 21 Project,Yonsei University College of Medicine,Seoul 03722,Republic of Korea [2]TMD LAB Co.Ltd.,6th Floor,31,Gwangnaru-ro 8-gil,Seongdong-gu,Seoul 04799,Republic of Korea

出　　处：《Research》2024年第1期165-180,共16页研究（英文）

基　　金：This study was financially supported by the Korea Medical Device Development Fund Grant funded by the Ministry of Science and iCT,the Ministry of Trade,Industry and Energy,the Ministry of Health&Welfare,the Ministry of Food and'Drug Safety(grant nos.1711138302 and KMDF_PR_20200901_0152-01);the National Research Foundation of Korea(NRF)funded by the Korean government(MSIT)(grant nos.2019R1A2C2010802 and 2021R1A6A3A13044778);the Brain Korea 21 PLUS Project for Medical Science of Yonsei University;the MD-PhD/Medical Scientist Training Program through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health and Welfare.

摘　　要：Tissue regeneration requires structural holding and movement support using tissue-type-specific aids such as bone casts,skin bandages,and joint protectors.Currently,an unmet need exists in aiding breast fat regeneration as the breast moves following continuous body motion by exposing the breast fat to dynamic stresses.Here,the concept of elastic structural holding is applied to develop a shape-fitting moldable membrane for breast fat regeneration(“adipoconductive”)after surgical defects are made.The membrane has the following key characteristics:(a)It contains a panel of honeycomb structures,thereby efficiently handling motion stress through the entire membrane;(b)a strut is added into each honeycomb in a direction perpendicular to gravity,thereby suppressing the deformation and stress concentration upon lying and standing;and(c)thermo-responsive moldable elastomers are used to support structural holding by suppressing large deviations of movement that occur sporadically.The elastomer became moldable upon a temperature shift above T_(m).The structure can then be fixed as the temperature decreases.As a result,the membrane promotes adipogenesis by activating mechanotransduction in a fat miniature model with pre-adipocyte spheroids under continuous shaking in vitro and in a subcutaneous implant placed on the motion-prone back areas of rodents in vivo.

关 键 词：thereby SHAKING ELASTIC 

分 类 号：R318[医药卫生—生物医学工程]