细胞焦亡与糖尿病肾病肾小管间质纤维化发病机制的研究进展  

Recent Findings Regarding the Role of Pyroptosis in the Development of Diabetic Nephropathy and Tubulointerstitial Fibrosis

作　　者：王欣茹 郭兆安[2] Wang Xinru;Guo Zhaoan(The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Jinan 250014;Nephrology Department,the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014)

机构地区：[1]山东中医药大学第一临床医学院,济南250014 [2]山东中医药大学附属医院肾病科,济南250014

出　　处：《国际老年医学杂志》2024年第3期348-351,共4页International Journal of Geriatrics

基　　金：山东省自然科学基金项目(202208310056)。

摘　　要：糖尿病肾病(DN)是致使病情进展至肾病末期阶段最主要的诱因,肾小管间质纤维化系推动DN肾功能恶化的关键因素,高糖环境下,炎症小体等诱导的程序性促细胞死亡方式--细胞焦亡,可促进肾小管间质纤维化,促进肾功能恶化。本文主要从DN引起肾小管间质纤维化的发病机制的角度,对抑制细胞焦亡从而阻止DN的进展作一综述,为DN提供一个新的治疗靶点和思路。Diabetic nephropathy(DN)is the primary factor leading to the advancement of end-stage renal disease.Tubulointerstitial fibrosis(TIF)is a crucial element that impacts renal function in DN.When exposed to high levels of glucose,the activation of inflammasomes can trigger cell death pathways,including pyroptosis.This can potentially lead to TIF,which in turn causes the decline of renal function.This article focuses on the pathogenic mechanisms of TIF resulting from DN.This study reviews the potential of blocking pyroptosis to slow down the course of DN,providing a new and promising target for therapeutic intervention in the treatment of DN.

关 键 词：糖尿病肾病 肾小管间质纤维化 细胞焦亡 

分 类 号：R587.2[医药卫生—内分泌] R692[医药卫生—内科学]