自体血清联合普拉洛芬治疗白内障人工晶体植入术后干眼症疗效评价  

Efficacy Evaluation of Autologous Serum Combined with Pranoprofen in the Treatment of Dry Eye Syndrome After Implantable Collamer Lens

作　　者：梁晓彦 杨洁 郭翠欣 马丽华 唐广贤 LIANG Xiaoyan;YANG Jie;GUO Cuixin;MA Lihua;TANG Guangxian(Shijiazhuang People′s Hospital,Shijiazhuang,Hebei,China 050000)

机构地区：[1]河北省石家庄市人民医院,河北石家庄050000

出　　处：《中国药业》2024年第10期104-107,共4页China Pharmaceuticals

基　　金：河北省石家庄市科学技术研究与发展自筹计划项目[221460833]。

摘　　要：目的探讨自体血清联合普拉洛芬治疗白内障人工晶体植入(ICL)术后干眼症的临床疗效。方法选取医院2019年1月至2022年5月收治的ICL术后干眼症患者110例,按用药方案的不同分为观察组和对照组,各55例。两组患者均予普拉洛芬滴眼液,观察组患者加用自体血清。两组患者均持续治疗3个月。结果观察组总有效率为98.18%,显著高于对照组的80.00%(P<0.05)。与对照组比较,观察组患者治疗1个月、3个月的泪膜破裂时间显著延长,泪液分泌长度显著增加(P<0.01),治疗2个月、3个月的角膜荧光素染色评分及治疗1个月、2个月、3个月的干眼症评分均显著降低(P<0.05)。观察组患者治疗后的白细胞介素1β、白细胞介素6、肿瘤坏死因子-α水平均显著降低,生活质量评分显著升高(P<0.05)。观察组患者治疗后的知觉正常比例为85.45%,显著高于对照组的67.27%(P<0.05)。结论自体血清联合普拉洛芬治疗ICL术后干眼症,能有效减轻患者眼部的炎性反应,改善干眼症症状。Objective To investigate the clinical efficacy of autologous serum combined with pranoprofen in the treatment of dry eye syndrome after implantable collamer lens(ICL).Methods A total of 110 patients with dry eye syndrome after ICL admitted to the hospital from January 2019 to May 2022 were selected and divided into the observation group and the control group based on different medication regimens,with 55 cases in each group.The patients in the two groups were given Pranoprofen Eye Drops,on this basis,the patients in the observation group were given autologous serum.Both groups were treated continuously for three months.Results The total effective rate in the observation group was 98.18%,which was significantly higher than 80.00%in the control group(P<0.05).Compared with those in the control group,the tear film break-up time(BUT)in the observation group significantly prolonged,the tear secretion length significantly increased at the one and three months of treatment(P<0.01).The corneal fluorescein staining score at the two and three months of treatment and dry eye syndrome score at the one,two and three months of treatment in the observation group significantly decreased(P<0.05).After treatment,the interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)levels in the observation group significantly decreased,and the quality of life score significantly increased(P<0.05).The proportion of patients with normal perception after treatment in the observation group was 85.45%,which was significantly higher than 67.27%in the control group(P<0.05).Conclusion Autologous serum combined with pranoprofen can effectively relieve the inflammatory reactions of eyes and improve symptoms of dry eye syndrome in patients after ICL.

关 键 词：自体血清 普拉洛芬 白内障 人工晶体植入术 干眼症 泪膜 稳定性 

分 类 号：R969.3[医药卫生—药理学]