虎黄烧伤搽剂联合常规疗法治疗Wagner 1-2级糖尿病足临床观察  

Clinical Observation of Huhuang Burn Liniment Combined with Conventional Therapy in the Treatment of Diabetic Foot of Wagner Grades 1-2

作　　者：王洪林[1] 沙前坤 钱妍[3] 彭期兵 WANG Honglin;SHA Qiankun;QIAN Yan;PENG Qibing(Dazu Hospital of Chongqing Medical University,Chongqing,China 402360;Chongqing Yangdu Biology Research Institute Co.,Ltd.,Chongqing,China 408000;The Second Affiliated Hospital of Chongqing Medical University,Chongqing,China 400010)

机构地区：[1]重庆医科大学附属大足医院,重庆402360 [2]重庆央都生物研究院有限公司,重庆408000 [3]重庆医科大学附属第二医院,重庆400010

出　　处：《中国药业》2024年第10期110-114,共5页China Pharmaceuticals

基　　金：重庆市自然科学基金面上项目[cstc2021jcyj-msxmX0367]。

摘　　要：目的探讨虎黄烧伤搽剂联合常规疗法治疗Wagner 1-2级糖尿病足的临床疗效。方法选取重庆医科大学附属大足医院2022年1月至2023年6月收治的Wagner 1-2级糖尿病足患者94例,按随机数字表法分为对照组和观察组,各47例。两组患者均予常规降糖药物,并以蚕食清创法清除坏死组织;观察组患者加用虎黄烧伤搽剂治疗。两组均连续治疗28 d。结果观察组疗效优于对照组(P<0.05);观察组糖尿病足感染率为2.13%,显著低于对照组的14.89%(P<0.05)。与对照组比较,观察组患者治疗第7,14,28天创面面积显著缩小,创面愈合时间显著缩短,创面组织中血管内皮生长因子(VEGF)、表皮生长因子(EGF)、基质金属蛋白酶抑制剂-1(TIMP-1)、转化生长因子-β(TGF-β)水平均显著升高,基质金属蛋白酶-9(MMP-9)水平显著降低(P<0.05)。结论虎黄烧伤搽剂联合常规疗法治疗Wagner 1-2级糖尿病足,可进一步上调创面组织中VEGF,EGF,TIMP-1,TGF-β水平,降低MMP-9水平,加速创面愈合。Objective To investigate the clinical efficacy of Huhuang Burn Liniment combined with conventional therapy in the treatment of diabetic foot of Wagner grades 1-2.Methods A total of 94 patients with diabetic foot of Wagner grades 1-2 admitted to the Dazu Hospital of Chongqing Medical University from January 2022 to June 2023 were selected and divided into the control group and the observation group by the random number table method,with 47 cases in each group.The patients in the two groups were treated with conventional hypoglycemic drugs,and the necrotic tissue was cleared by the silkworm-feeding debridement method,on this basis,the patients in the observation group were treated with Huhuang Burn Liniment.Both groups were treated continuously for 28 d.Results The efficacy in the observation group was better than that in the control group(P<0.05).The infection rate of diabetic foot in the observation group was 2.13%,which was significantly lower than 14.89%in the control group(P<0.05).Compared with those in the control group,the wound surface area in the observation group significantly decreased,the wound surface healing time significantly shortened,the vascular endothelial growth factor(VEGF),epidermal growth factor(EGF),tissue inhibitor of metalloproteinases-1(TIMP-1)and transforming growth factor-β(TGF-β)levels significantly increased,the matrix metalloproteinase-9(MMP-9)level significantly decreased on the 7th,14th and 28th days of treatment(P<0.05).Conclusion Huhuang Burn Liniment combined with conventional therapy in the treatment of diabetic foot of Wagner grades 1-2 can increase the VEGF,EGF,TIMP-1,TGF-βlevels,decrease the MMP-9 level,and promote the wound surface healing.

关 键 词：虎黄烧伤搽剂 糖尿病足 血管内皮生长因子 表皮生长因子 基质金属蛋白酶抑制剂-1 基质金属蛋白酶-9 转化生长因子-Β 临床疗效 

分 类 号：R969.4[医药卫生—药理学]