榄香烯治疗老年难治/复发性急性髓系白血病个案报道并文献分析  

Elemene in the Treatment of Elderly Refractory/Recurrent Acute Myeloid Leukemia:A Case Report and Literature Analysis

作　　者：张建新 文孝男 黄泳立[2] 林波 李宏良[2] ZHANG Jianxin;WEN Xiaonan;HUANG Yongli;LIN Bo;LI Hongliang(Foshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine,Foshan,Guangdong,China 528000;Foshan Hospital of Traditional Chinese Medicine,Foshan,Guangdong,China 528000)

机构地区：[1]广州中医药大学附属佛山中医院,广东佛山528000 [2]广东省佛山市中医院,广东佛山528000

出　　处：《中国药业》2024年第10期128-128,I0001-I0005,共6页China Pharmaceuticals

摘　　要：目的为榄香烯治疗白血病的深入研究提供参考。方法回顾1例老年(65岁)难治/复发性急性髓系白血病(AML)患者复发后用榄香烯治疗获得骨髓完全缓解的过程,结合文献分析探索该方案的有效性及榄香烯可能的作用机制。结果该患者确诊后曾使用多种化学药物治疗(简称化疗)方案治疗,有一定疗效,但多次出现Ⅳ度骨髓抑制等不良反应,且疾病出现复发。使用榄香烯治疗后,原始细胞消失,微小残留病变持续阴性,生活质量明显提高。既往研究表明,榄香烯可通过直接的细胞毒作用,促进肿瘤细胞凋亡,逆转多药耐药性等机制抑制白血病细胞生长。结论榄香烯可能通过调节多种关键信号通路治疗白血病,但具体机制和相关靶点尚未明晰。Objective To provide a reference for further research of elemene in the treatment of leukemia.Methods The treatment process of an elderly(65 years)patient with refractory/recurrent acute myeloid leukemia(AML)who achieved complete bone marrow remission after receiving elemene when the disease recurred was retrospectively analyzed,the effectiveness of the regimen and the possible mechanism of elemene were analyzed and explored based on the literature.Results After diagnosis,the patient had received multiple chemotherapy regimens with a certain efficacy,but she experienced multiple adverse reactions such as bone marrow suppression of gradeⅣand recurrent disease.After treatment with elemene,the patient′s primitive cells disappeared,minimal residual disease remained negative,and her quality of life significantly improved.Previous studies showed that elemene could inhibit the growth of leukemia cells through mechanisms such as direct cytotoxic effects,promotion of tumor cell apoptosis and reversal of multi-drug resistance.Conclusion Elemene may treat leukemia by regulating multiple key signaling pathways,but the specific mechanism and related targets are not yet clear.

关 键 词：榄香烯 老年 难治性急性髓系白血病 复发性急性髓系白血病 病例分析 文献分析 药学监护 

分 类 号：R969.4[医药卫生—药理学]