N端脑钠肽、同型半胱氨酸、D-二聚体、纤维蛋白原水平与急性脑梗死疾病严重程度的相关性分析  

Correlation Analysis of N-terminal Brain Natriuretic Peptide,Homocyste⁃ine,D-Dimer,and Fibrinogen Levels with Disease Severity in Acute Cere⁃bral Infarction

作　　者：倪文伟 NI Wenwei(Department of Laboratory,Nantong Ruici Hospital,Nantong,Jiangsu Province,226010 China)

机构地区：[1]南通市瑞慈医院检验科,江苏南通226010

出　　处：《系统医学》2024年第6期1-4,共4页Systems Medicine

摘　　要：目的探究N端脑钠肽、同型半胱氨酸、纤维蛋白原、D-二聚体与急性脑梗死严重程度的相关性。方法选取2021年2月—2023年8月南通市瑞慈医院收治的118例急性脑梗死患者为研究对象,患者入院后使用美国国立卫生院卒中量表(National National Health Stroke Scale,NIHSS)对患者疾病严重程度进行评估,根据NIHSS评分将患者分成轻度组(n=35)、中度组(n=46)和重度组(n=37),对比3组患者N端脑钠肽、血清同型半胱氨酸、纤维蛋白原、D-二聚体水平,分析上述指标与急性脑梗死疾病严重程度的相关性。结果3组同型半胱氨酸水平对比,差异无统计学意义(P>0.05);轻度组N端脑钠肽、纤维蛋白原、D-二聚体水平低于中度组和重度组,差异有统计学意义(P均<0.05)。N端脑钠肽、D-二聚体、纤维蛋白原水平与急性脑梗死严重程度呈正相关(r=0.95、0.30、0.78,P均<0.05)。结论N端脑钠肽、纤维蛋白原、D-二聚体与急性脑梗死的严重程度呈正相关,可以作为疾病严重程度的反馈指标。Objective To investigate the correlation between N-terminal brain natriuretic peptide,homocysteine,fibrinogen,D-dimer and the severity of acute cerebral infarction.Methods 118 patients with acute cerebral infarction admitted to Nantong Ruici Hospital from February 2021 to August 2023 were selected as the study objects.Patients'disease severity was assessed according to the National Institutes of Health Stroke Scale(NIHSS)after admission,and they were divided into mild group(n=35),moderate group(n=46),and severe group(n=37)based on their NIHSS scores.N-terminal brain natriuretic peptide,serum homocysteine,fibrinogen,D-dimer levels of patients in the three groups were compared between the three groups.Correlation between the indicators above and the severity of acute cerebral infarction disease were analyzed.Results There was no significant difference in the comparison of homocysteine levels among the three groups(P>0.05).N-terminal brain natriuretic peptide,fibrinogen,and D-dimer levels in the mild group were lower than those of the moderate group and the severe group,and the differences were statistically significant(all P<0.05).The levels of N-terminal brain natriuretic peptide,D-dimer,and fibrinogen had positive correlations with the severity of acute cerebral infarction(r=0.95,0.30,0.78,all P<0.05).Conclusion N-terminal brain natriuretic peptide,fibrinogen,D-dimer have positive correlations with severity of acute cerebral infarction,and can be used as a feedback indicator of disease severity.

关 键 词：N端脑钠肽 同型半胱氨酸 D-二聚体 纤维蛋白原 急性脑梗死 严重程度 相关性 

分 类 号：R446.1[医药卫生—诊断学]