达格列净联合沙库巴曲缬沙坦对早期肥胖型糖尿病肾病患者糖代谢和肾功能的影响  

Effects of Dapagliflozin Combined with Sackubactril Valsartan on Glucose Metabolism and Renal Function in Early Obese Diabetic Nephropathy Pa⁃tients

作　　者：孙莹 SUN Ying(Department of Nephrology,Mengyin County People's Hospital,Linyi,Shandong Province,276200 China)

机构地区：[1]山东省临沂市蒙阴县人民医院肾内科,山东临沂276200

出　　处：《系统医学》2024年第6期100-102,111,共4页Systems Medicine

摘　　要：目的探究达格列净联合沙库巴曲缬沙坦对早期肥胖型糖尿病肾病(Obese Diabetes Nephropathy,ODN)患者糖代谢和肾功能的影响。方法选取山东省临沂市蒙阴县人民医院于2021年1月—2023年9月收治的100例早期ODN患者作为研究对象,采取随机数法将患者分为观察组和研究组,各50例。对照组使用达格列净治疗,观察组在对照组基础上加用沙库巴曲缬沙坦治疗。比较两组患者治疗前后血糖水平、肾功能指标以及疗效。结果治疗后,观察组患者血糖水平明显低于对照组,差异有统计学意义(P<0.05);观察组患者肾功能明显优于对照组,差异有统计学意义(P<0.05);观察组治疗有效率(98.00%)明显高于对照组(82.00%),差异有统计学意义(χ^(2)=7.111,P<0.05)。结论达格列净联合沙库巴曲缬沙坦有效降低早期肥胖型糖尿病肾病患者的血糖水平,改善患者的肾功能。Objective To explore the effects of dagliagin combined with sakubactril valsartan on glucose metabolism and renal function in patients with early Obese Diabetes Nephropathy(ODN).Methods A total of 100 early ODN pa tients admitted to Mengyin County People's Hospital of Linyi City,Shandong Province from January 2021 to Septem ber 2023 were selected as the study objects.Random number method was used to divide the patients into observation group and research group,with 50 cases in each group.The control group was treated with daglipzin,and the observa tion group was treated with sakubatrol valsartan on the basis of the control group.The blood glucose level,renal func tion index and efficacy of the two groups of patients were compared before and after treatment.Results After treat ment,the blood glucose level of observation group was significantly lower than that of control group,and the difference was statistically significant(P<0.05).The renal function of observation group was significantly better than that of con trol group,and the difference was statistically significant(P<0.05).The therapeutic effective rate of observation group(98.00%)was significantly higher than that of control group(82.00%),and the difference was statistically significant(χ^(2)=7.111,P<0.05).Conclusion Daglipzin combined with sackubactril valsartan can effectively reduce blood glucose level and improve renal function in early obese diabetic nephropathy patients.

关 键 词：达格列净 沙库巴曲缬沙坦 早期肥胖型糖尿病肾病 糖代谢 肾功能 

分 类 号：R4[医药卫生—临床医学]