左西孟旦对高龄急性心肌梗死合并心力衰竭疾病的效果分析  

Analysis of the Effect of Levosimendan on Acute Myocardial Infarction Combined with Heart Failure in Elderly People

作　　者：喻澄 曹苏岩 董丰[1] 陈浩[1] YU Cheng;CAO Suyan;DONG Feng;CHEN Hao(Department of Cardiology,Wuxi Second People's Hospital,Wuxi,Jiangsu Province,214000 China)

机构地区：[1]无锡市第二人民医院心内科,江苏无锡214000

出　　处：《系统医学》2024年第6期116-120,共5页Systems Medicine

摘　　要：目的研究左西孟旦在高龄急性心肌梗死合并心力衰竭患者治疗中的有效性和安全性。方法选取2020年1月—2023年1月无锡市第二人民医院心内科收治的42例高龄急性心肌梗死合并心力衰竭患者为研究对象,选用随机数表法将其分成对照组和观察组,每组21例。对照组给予常规治疗,观察组在常规治疗基础上给予左西孟旦治疗1次,持续24 h,比较两组临床疗效、生命体征、血清N末端脑钠肽前体(N-Terminal Brain Natriuretic Peptide,NT-proBNP)、超声心动图相关指标、低血压或快速性心律失常等不良反应的发生率、随访半年内主要心血管不良事件发生率。结果治疗前,对比两组患者的生命体征(心率、收缩压、舒张压、呼吸频率)、脑钠肽水平和心功能(左室射血分数、左室舒张末期内径、左室短轴缩短率),差异无统计学意义(P均>0.05)。治疗后,观察组治疗总有效率高于对照组,NT-proBNP低于对照组,心功能优于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。观察组的住院时间短于对照组,治疗费用少于对照组,差异有统计学意义(P均<0.05)。两组病死率、再住院率、心血管不良事件发生率比较,差异无统计学意义(P均>0.05)。结论左西孟旦在高龄急性心肌梗死合并心力衰竭患者中效果较好,能够迅速改善临床症状,降低脑钠肽水平,改善心功能,没有增加低血压、房颤、室速等不良反应,但对于远期预后没有改善,可缩短住院天数,减轻患者医疗负担。Objective To study the effectiveness and safety of levosimendan in the treatment of elderly patients with acute myocardial infarction combined with heart failure.Methods A total of 42 elderly patients with acute myocardial infarction complicated with heart failure admitted to the Department of Cardiology,Wuxi Second People's Hospital from January 2020 to January 2023 were selected as the research objects.They were divided into control group and ob servation group by random number table method,with 21 cases in each group.The control group was given conven tional treatment,and the observation group was given levosimendan once for 24 h on the basis of conventional treat ment.The two groups were compared in terms of clinical efficacy,vital signs,serum N-terminal brain natriuretic pep tide(NT-proBNP),echocardiography-related indexes,the occurrence of adverse reactions such as hypotension or tachyarrhythmia,and the occurrence of major adverse event rate(MACE)during the 6 month follow-up.Results Be fore treatment,the vital signs(heart rate,systolic blood pressure,diastolic blood pressure,respiratory rate),brain natri uretic peptide levels,and cardiac function(left ventricular ejection fraction,left ventricular end diastolic diameter,and left ventricular short axis shortening rate)were compared between the two groups of patients,and there was no sta tistically significant difference(all P>0.05).After treatment,the total effective rate of treatment the observation group was higher than that of the control group,the level of NT-proBNP was lower than that of the control group,and the heart function was better than that of the control group,the differences were statistically significant(all P<0.05).The incidence of adverse reactions in both groups was relatively low,and the difference was not statistically significant(P>0.05).The hospitalization time of the observation group was shorter than that of the control group,and the treatment cost was less than that of the control group,the differences were statistically significant

关 键 词：左西孟旦 高龄急性心肌梗死 心力衰竭 临床疗效 心功能 远期预后 

分 类 号：R542.22[医药卫生—心血管疾病] R541.6[医药卫生—内科学]